Simulation scenario 2, HS phase

Setting description

TC2 more effective in all the biomarker signatures

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4
all	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
all	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
all	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
HRD+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
HRD+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
HRD+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
TP53+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
TP53+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
TEfus+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
TEfus+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
PI3K+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
PI3K+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
PI3K+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4
—-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
—-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
—+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–+-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
–+-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
–++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+–	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
-+–	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+-+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
-+-+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-++-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
-++-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
-+++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+—	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
+—	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+–+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
+–+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+-+-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
+-+-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+-++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
+-++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
++–	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
++–	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
++-+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
++-+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+++-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
+++-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
++++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
++++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 all 1 330 4 5 HRD+ 0 66 6 11 TP53+ 2 267 3 4 TEfus+ 0 183 1 3 PI3K+ 1 194 3 0

TC1 TC2 TC3 TC4 all 0.002 0.660 0.008 0.010 HRD+ 0.000 0.132 0.012 0.022 TP53+ 0.004 0.534 0.006 0.008 TEfus+ 0.000 0.366 0.002 0.006 PI3K+ 0.002 0.388 0.006 0.000

futility (counts and proportions):

TC1 TC2 TC3 TC4 all 103 0 26 39 HRD+ 28 0 37 31 TP53+ 294 1 159 182 TEfus+ 191 1 129 107 PI3K+ 240 0 125 164

TC1 TC2 TC3 TC4 all 0.206 0.000 0.052 0.078 HRD+ 0.056 0.000 0.074 0.062 TP53+ 0.588 0.002 0.318 0.364 TEfus+ 0.382 0.002 0.258 0.214 PI3K+ 0.480 0.000 0.250 0.328

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

Operating characteristics

Characteristics	Overall	TC1	TC2	TC3	TC4
Error signature	0.334	0.008	0.272	0.034	0.044
Error subgroup	0.086	0.008	0.000	0.034	0.044
Power signature	0.660	0.000	0.660	0.000	0.000
Power subgroup	0.932	0.000	0.932	0.000	0.000

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4
all	graduation	0	1	330	4	5
all	futility	0	103	0	26	39
all	max_n	0	0	0	0	0
all	n	658 (606, 706)	209 (151, 304)	301 (94, 503)	298 (194, 443)	290 (176, 438)
all	n_unique	658 (606, 706)	209 (151, 304)	301 (94, 503)	298 (194, 443)	290 (176, 438)
all	time_trial	60 (60, 60)	60 (46, 60)	42 (14, 60)	60 (60, 60)	60 (60, 60)
all	time_stop	NA (NA, NA)	46 (34, 57)	29 (13, 50)	50 (18, 59)	38 (17, 58)
all	post_p	NA (NA, NA)	0 (0, 0.03)	1 (1, 1)	0.05 (0, 0.35)	0.05 (0, 0.35)
all	rate	0.018 (0.016, 0.019)	0.025 (0.023, 0.029)	0.011 (0.009, 0.012)	0.021 (0.019, 0.024)	0.021 (0.019, 0.024)
HRD+	graduation	0	0	66	6	11
HRD+	futility	0	28	0	37	31
HRD+	max_n	0	0	0	0	0
HRD+	n	89 (74, 103)	38 (23, 57)	34 (8, 58)	47 (30, 66)	48 (26, 71)
HRD+	n_unique	89 (74, 103)	38 (23, 57)	34 (8, 58)	47 (30, 66)	48 (26, 71)
HRD+	time_trial	60 (60, 60)	60 (60, 60)	60 (56, 60)	60 (60, 60)	60 (60, 60)
HRD+	time_stop	NA (NA, NA)	54 (49, 58)	52 (44, 58)	51 (42, 59)	52 (43, 58)
HRD+	post_p	NA (NA, NA)	0.11 (0.01, 0.51)	0.94 (0.63, 1)	0.19 (0.03, 0.64)	0.28 (0.04, 0.72)
HRD+	rate	0.018 (0.014, 0.022)	0.025 (0.019, 0.034)	0.01 (0.006, 0.016)	0.023 (0.017, 0.03)	0.021 (0.016, 0.028)
TP53+	graduation	0	2	267	3	4
TP53+	futility	0	294	1	159	182
TP53+	max_n	0	0	0	0	0
TP53+	n	240 (211, 267)	78 (50, 135)	91 (40, 172)	116 (55, 183)	106 (52, 184)
TP53+	n_unique	240 (211, 267)	78 (50, 135)	91 (40, 172)	116 (55, 183)	106 (52, 184)
TP53+	time_trial	60 (60, 60)	53 (32, 60)	56 (30, 60)	60 (35, 60)	60 (32, 60)
TP53+	time_stop	NA (NA, NA)	42 (28, 56)	39 (27, 54)	40 (28, 56)	39 (27, 56)
TP53+	post_p	NA (NA, NA)	0.03 (0, 0.23)	1 (0.95, 1)	0.15 (0.01, 0.58)	0.15 (0.01, 0.59)
TP53+	rate	0.018 (0.015, 0.02)	0.026 (0.021, 0.031)	0.011 (0.009, 0.013)	0.021 (0.017, 0.026)	0.021 (0.018, 0.027)
TEfus+	graduation	0	0	183	1	3
TEfus+	futility	0	191	1	129	107
TEfus+	max_n	0	0	0	0	0
TEfus+	n	204 (178, 232)	78 (50, 124)	75 (30, 147)	103 (57, 156)	98 (53, 152)
TEfus+	n_unique	204 (178, 232)	78 (50, 124)	75 (30, 147)	103 (57, 156)	98 (53, 152)
TEfus+	time_trial	60 (60, 60)	60 (39, 60)	60 (33, 60)	60 (40, 60)	60 (44, 60)
TEfus+	time_stop	NA (NA, NA)	45 (33, 57)	39 (26, 56)	44 (31, 58)	45 (33, 57)
TEfus+	post_p	NA (NA, NA)	0.04 (0, 0.26)	1 (0.92, 1)	0.15 (0.02, 0.55)	0.16 (0.01, 0.58)
TEfus+	rate	0.017 (0.015, 0.02)	0.025 (0.02, 0.031)	0.011 (0.008, 0.013)	0.021 (0.018, 0.026)	0.021 (0.018, 0.027)
PI3K+	graduation	0	1	194	3	0
PI3K+	futility	0	240	0	125	164
PI3K+	max_n	0	0	0	0	0
PI3K+	n	223 (194, 249)	82 (51, 134)	78 (29, 155)	114 (60, 176)	102 (54, 164)
PI3K+	n_unique	223 (194, 249)	82 (51, 134)	78 (29, 155)	114 (60, 176)	102 (54, 164)
PI3K+	time_trial	60 (60, 60)	60 (34, 60)	60 (30, 60)	60 (41, 60)	60 (33, 60)
PI3K+	time_stop	NA (NA, NA)	43 (29, 55)	38 (25, 54)	44 (31, 56)	38 (26, 56)
PI3K+	post_p	NA (NA, NA)	0.03 (0, 0.25)	1 (0.91, 1)	0.18 (0.01, 0.6)	0.15 (0.01, 0.55)
PI3K+	rate	0.017 (0.015, 0.02)	0.025 (0.021, 0.031)	0.01 (0.008, 0.013)	0.021 (0.017, 0.026)	0.022 (0.019, 0.027)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4
—-	graduation	0	1	330	4	5
—-	futility	0	103	0	26	39
—-	max_n	0	0	0	0	0
—-	n	212 (180, 240)	37 (23, 87)	112 (28, 211)	62 (24, 173)	64 (25, 174)
—-	n_unique	212 (180, 240)	37 (23, 87)	112 (28, 211)	62 (24, 173)	64 (25, 174)
—-	post_p	NA (NA, NA)	0.06 (0, 0.31)	1 (0.92, 1)	0.18 (0.02, 0.63)	0.19 (0.03, 0.62)
—-	rate	0.018 (0.015, 0.02)	0.027 (0.022, 0.035)	0.01 (0.008, 0.013)	0.022 (0.017, 0.03)	0.021 (0.017, 0.029)
—+	graduation	0	2	384	7	5
—+	futility	0	254	0	130	174
—+	max_n	0	0	0	0	0
—+	n	46 (36, 56)	15 (8, 35)	15 (4, 40)	23 (9, 45)	18 (8, 41)
—+	n_unique	46 (36, 56)	15 (8, 35)	15 (4, 40)	23 (9, 45)	18 (8, 41)
—+	post_p	NA (NA, NA)	0.2 (0.04, 0.57)	0.86 (0.46, 0.98)	0.36 (0.07, 0.76)	0.31 (0.07, 0.66)
—+	rate	0.017 (0.012, 0.023)	0.026 (0.018, 0.042)	0.01 (0.005, 0.019)	0.021 (0.014, 0.034)	0.022 (0.015, 0.037)
–+-	graduation	0	1	379	5	8
–+-	futility	0	215	1	131	119
–+-	max_n	0	0	0	0	0
–+-	n	13 (8, 18)	6 (3, 12)	5 (2, 11)	7 (3, 13)	7 (3, 13)
–+-	n_unique	13 (8, 18)	6 (3, 12)	5 (2, 11)	7 (3, 13)	7 (3, 13)
–+-	post_p	NA (NA, NA)	0.39 (0.14, 0.65)	0.66 (0.39, 0.88)	0.42 (0.18, 0.72)	0.46 (0.2, 0.73)
–+-	rate	0.018 (0.009, 0.032)	0.026 (0.012, 0.056)	0.01 (0, 0.027)	0.022 (0.009, 0.046)	0.022 (0.009, 0.049)
–++	graduation	0	2	422	6	8
–++	futility	0	313	1	198	217
–++	max_n	0	0	0	0	0
–++	n	68 (55, 82)	20 (10, 49)	24 (9, 56)	30 (11, 62)	24 (12, 60)
–++	n_unique	68 (55, 82)	20 (10, 49)	24 (9, 56)	30 (11, 62)	24 (12, 60)
–++	post_p	NA (NA, NA)	0.17 (0.02, 0.52)	0.92 (0.64, 1)	0.3 (0.06, 0.73)	0.27 (0.04, 0.7)
–++	rate	0.017 (0.013, 0.022)	0.026 (0.018, 0.039)	0.011 (0.007, 0.016)	0.021 (0.015, 0.034)	0.023 (0.016, 0.033)
-+–	graduation	0	3	413	7	9
-+–	futility	0	313	1	162	195
-+–	max_n	0	0	0	0	0
-+–	n	87 (70, 101)	20 (10, 49)	33 (14, 76)	33 (13, 75)	33 (12, 77)
-+–	n_unique	87 (70, 101)	20 (10, 49)	33 (14, 76)	33 (13, 75)	33 (12, 77)
-+–	post_p	NA (NA, NA)	0.14 (0.01, 0.47)	0.96 (0.73, 1)	0.29 (0.06, 0.7)	0.29 (0.04, 0.75)
-+–	rate	0.018 (0.014, 0.022)	0.027 (0.02, 0.04)	0.011 (0.007, 0.016)	0.022 (0.016, 0.032)	0.021 (0.015, 0.032)
-+-+	graduation	0	4	430	8	9
-+-+	futility	0	362	1	217	248
-+-+	max_n	0	0	0	0	0
-+-+	n	56 (42, 69)	16 (9, 40)	19 (7, 43)	25 (9, 52)	21 (10, 51)
-+-+	n_unique	56 (42, 69)	16 (9, 40)	19 (7, 43)	25 (9, 52)	21 (10, 51)
-+-+	post_p	NA (NA, NA)	0.19 (0.04, 0.56)	0.9 (0.58, 0.99)	0.33 (0.08, 0.72)	0.29 (0.07, 0.7)
-+-+	rate	0.017 (0.013, 0.023)	0.026 (0.017, 0.04)	0.011 (0.006, 0.017)	0.022 (0.015, 0.034)	0.023 (0.016, 0.034)
-++-	graduation	0	3	440	8	10
-++-	futility	0	370	1	230	241
-++-	max_n	0	0	0	0	0
-++-	n	49 (37, 63)	14 (8, 35)	18 (8, 40)	22 (8, 46)	20 (8, 45)
-++-	n_unique	49 (37, 63)	14 (8, 35)	18 (8, 40)	22 (8, 46)	20 (8, 45)
-++-	post_p	NA (NA, NA)	0.21 (0.05, 0.56)	0.89 (0.6, 0.98)	0.32 (0.07, 0.71)	0.32 (0.07, 0.71)
-++-	rate	0.017 (0.012, 0.023)	0.026 (0.018, 0.04)	0.011 (0.006, 0.017)	0.022 (0.015, 0.034)	0.022 (0.014, 0.036)
-+++	graduation	0	4	452	8	10
-+++	futility	0	399	1	266	283
-+++	max_n	0	0	0	0	0
-+++	n	37 (27, 48)	12 (6, 32)	12 (5, 24)	17 (7, 37)	15 (7, 37)
-+++	n_unique	37 (27, 48)	12 (6, 32)	12 (5, 24)	17 (7, 37)	15 (7, 37)
-+++	post_p	NA (NA, NA)	0.24 (0.05, 0.6)	0.83 (0.47, 0.97)	0.37 (0.09, 0.71)	0.34 (0.09, 0.75)
-+++	rate	0.017 (0.012, 0.024)	0.026 (0.016, 0.044)	0.011 (0.005, 0.019)	0.021 (0.014, 0.036)	0.022 (0.015, 0.037)
+—	graduation	0	1	372	10	16
+—	futility	0	127	0	59	68
+—	max_n	0	0	0	0	0
+—	n	42 (33, 52)	14 (7, 32)	14 (3, 34)	18 (10, 35)	20 (9, 39)
+—	n_unique	42 (33, 52)	14 (7, 32)	14 (3, 34)	18 (10, 35)	20 (9, 39)
+—	post_p	NA (NA, NA)	0.23 (0.04, 0.57)	0.84 (0.48, 0.98)	0.31 (0.06, 0.74)	0.37 (0.09, 0.78)
+—	rate	0.017 (0.013, 0.025)	0.026 (0.018, 0.045)	0.01 (0.005, 0.02)	0.023 (0.015, 0.036)	0.021 (0.014, 0.035)
+–+	graduation	0	2	411	13	16
+–+	futility	0	267	0	153	189
+–+	max_n	0	0	0	0	0
+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
+–+	rate	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.013 (0, 0.444)	0.032 (0.032, 0.032)
+-+-	graduation	0	1	414	11	19
+-+-	futility	0	233	1	155	142
+-+-	max_n	0	0	0	0	0
+-+-	n	30 (22, 39)	12 (5, 24)	9 (2, 22)	14 (7, 26)	14 (6, 27)
+-+-	n_unique	30 (22, 39)	12 (5, 24)	9 (2, 22)	14 (7, 26)	14 (6, 27)
+-+-	post_p	NA (NA, NA)	0.26 (0.06, 0.66)	0.79 (0.41, 0.96)	0.33 (0.08, 0.7)	0.4 (0.1, 0.77)
+-+-	rate	0.018 (0.012, 0.025)	0.027 (0.015, 0.048)	0.01 (0.002, 0.023)	0.023 (0.015, 0.04)	0.021 (0.012, 0.04)
+-++	graduation	0	2	442	12	19
+-++	futility	0	323	1	215	230
+-++	max_n	0	0	0	0	0
+-++	n	6 (3, 10)	3 (1, 7)	2 (0, 5)	4 (1, 8)	4 (1, 8)
+-++	n_unique	6 (3, 10)	3 (1, 7)	2 (0, 5)	4 (1, 8)	4 (1, 8)
+-++	post_p	NA (NA, NA)	0.45 (0.26, 0.62)	0.56 (0.41, 0.73)	0.47 (0.27, 0.66)	0.47 (0.29, 0.64)
+-++	rate	0.016 (0, 0.038)	0.028 (0, 0.071)	0.009 (0, 0.038)	0.022 (0.005, 0.065)	0.023 (0.005, 0.056)
++–	graduation	0	3	434	12	20
++–	futility	0	325	1	185	206
++–	max_n	0	0	0	0	0
++–	n	1 (0, 3)	1 (0, 2)	0 (0, 1)	1 (0, 2)	1 (0, 2)
++–	n_unique	1 (0, 3)	1 (0, 2)	0 (0, 1)	1 (0, 2)	1 (0, 2)
++–	post_p	NA (NA, NA)	0.49 (0.42, 0.56)	0.53 (0.44, 0.57)	0.49 (0.43, 0.56)	0.5 (0.44, 0.55)
++–	rate	0.008 (0, 0.075)	0.022 (0, 0.126)	0 (0, 0.045)	0.019 (0, 0.126)	0.018 (0, 0.095)
++-+	graduation	0	4	449	13	20
++-+	futility	0	369	1	233	255
++-+	max_n	0	0	0	0	0
++-+	n	8 (4, 13)	4 (1, 8)	2 (0, 6)	5 (2, 10)	4 (2, 11)
++-+	n_unique	8 (4, 13)	4 (1, 8)	2 (0, 6)	5 (2, 10)	4 (2, 11)
++-+	post_p	NA (NA, NA)	0.43 (0.22, 0.64)	0.59 (0.4, 0.82)	0.45 (0.25, 0.72)	0.46 (0.24, 0.68)
++-+	rate	0.017 (0.006, 0.035)	0.026 (0.009, 0.068)	0.009 (0, 0.035)	0.023 (0.009, 0.055)	0.023 (0.009, 0.061)
+++-	graduation	0	3	456	13	21
+++-	futility	0	382	1	248	251
+++-	max_n	0	0	0	0	0
+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
+++-	rate	0 (0, 0)	0.046 (0.046, 0.046)	0 (0, 0.037)	0.006 (0, 0.038)	0 (0, 0.057)
++++	graduation	0	4	466	13	21
++++	futility	0	406	1	279	289
++++	max_n	0	0	0	0	0
++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	post_p	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)	0.43 (0.43, 0.43)	NA (NA, NA)
++++	rate	0 (0, 0.07)	0.019 (0, 0.054)	0 (0, 0.143)	0.044 (0, 0.13)	0 (0, 0.128)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4
all	count	1	330	4	5
all	time_stop	10 (10, 10)	29 (13, 50)	12 (11, 17)	16 (12, 30)
all	n_trt	59 (59, 59)	200 (84, 382)	66 (56, 83)	66 (59, 206)
all	n_control	99 (99, 99)	258 (102, 514)	104 (100, 131)	129 (107, 275)
all	post_p	0.86 (0.86, 0.86)	1 (0.93, 1)	0.9 (0.86, 0.96)	0.92 (0.89, 0.93)
all	order	1 (1, 1)	1 (1, 3)	1 (1, 1)	1 (1, 1.6)
HRD+	count		66	6	11
HRD+	time_stop		52 (44, 58)	46 (42, 53)	47 (40, 55)
HRD+	n_trt		52 (50, 65)	54 (50, 58)	51 (51, 64)
HRD+	n_control		72 (52, 85)	59 (47, 70)	58 (45, 74)
HRD+	post_p		0.99 (0.92, 1)	0.92 (0.89, 0.98)	0.95 (0.87, 0.99)
HRD+	order		2 (1, 3)	2.5 (2, 4.5)	2 (1, 5)
TP53+	count	2	267	3	4
TP53+	time_stop	28 (23, 34)	39 (28, 54)	37 (31, 39)	26 (23, 50)
TP53+	n_trt	60 (53, 66)	88 (57, 145)	61 (59, 79)	70 (58, 180)
TP53+	n_control	88 (70, 105)	133 (83, 207)	127 (112, 130)	80 (61, 215)
TP53+	post_p	0.97 (0.95, 0.98)	0.99 (0.95, 1)	0.95 (0.94, 0.97)	0.92 (0.88, 0.96)
TP53+	order	1.5 (1.1, 1.9)	2 (1, 3)	2 (2, 2.8)	1 (1, 3.1)
TEfus+	count		183	1	3
TEfus+	time_stop		39 (26, 56)	39 (39, 39)	35 (33, 43)
TEfus+	n_trt		78 (54, 117)	134 (134, 134)	78 (56, 118)
TEfus+	n_control		116 (71, 184)	133 (133, 133)	99 (93, 118)
TEfus+	post_p		0.99 (0.95, 1)	0.9 (0.9, 0.9)	0.97 (0.94, 0.99)
TEfus+	order		2 (1, 4)	2 (2, 2)	2 (1.2, 2)
PI3K+	count	1	194	3
PI3K+	time_stop	28 (28, 28)	38 (25, 54)	26 (24, 27)
PI3K+	n_trt	54 (54, 54)	78 (54, 131)	54 (52, 67)
PI3K+	n_control	72 (72, 72)	120 (72, 182)	77 (62, 94)
PI3K+	post_p	0.93 (0.93, 0.93)	0.99 (0.95, 1)	0.93 (0.89, 0.98)
PI3K+	order	1 (1, 1)	2 (1, 4)	1 (1, 1.8)

Futility:

signature	var	TC1	TC2	TC3	TC4
all	count	103		26	39
all	time_stop	46 (34, 57)		54 (36, 59)	47 (27, 59)
all	n_trt	164 (128, 231)		188 (148, 316)	154 (111, 249)
all	n_control	474 (305, 623)		546 (324, 668)	458 (243, 607)
all	post_p	0 (0, 0.03)		0.01 (0, 0.04)	0.01 (0, 0.06)
all	order	3 (2, 6)		4 (2.5, 6)	3 (1, 6)
HRD+	count	28		37	31
HRD+	time_stop	54 (49, 58)		52 (41, 59)	55 (45, 59)
HRD+	n_trt	52 (50, 63)		53 (50, 66)	52 (50, 61)
HRD+	n_control	86 (63, 95)		77 (57, 99)	78 (56, 98)
HRD+	post_p	0.05 (0.02, 0.17)		0.08 (0.02, 0.24)	0.09 (0.03, 0.22)
HRD+	order	4 (2, 6.3)		4 (2, 7)	4 (2, 8)
TP53+	count	294	1	159	182
TP53+	time_stop	42 (29, 56)	27 (27, 27)	40 (28, 56)	39 (27, 56)
TP53+	n_trt	68 (51, 108)	71 (71, 71)	72 (51, 128)	66 (51, 118)
TP53+	n_control	148 (91, 222)	91 (91, 91)	143 (91, 222)	137 (82, 219)
TP53+	post_p	0.05 (0.01, 0.18)	0.05 (0.05, 0.05)	0.07 (0.01, 0.23)	0.09 (0.01, 0.23)
TP53+	order	2 (1, 5)	3 (3, 3)	2 (1, 5)	2 (1, 5)
TEfus+	count	191	1	129	107
TEfus+	time_stop	45 (33, 57)	32 (32, 32)	45 (31, 58)	45 (33, 57)
TEfus+	n_trt	65 (51, 106)	60 (60, 60)	68 (51, 117)	67 (50, 106)
TEfus+	n_control	141 (94, 193)	81 (81, 81)	144 (82, 199)	141 (92, 197)
TEfus+	post_p	0.03 (0, 0.15)	0.15 (0.15, 0.15)	0.05 (0.01, 0.17)	0.06 (0.01, 0.15)
TEfus+	order	3 (1, 5)	1 (1, 1)	3 (1, 6)	3 (1, 6)
PI3K+	count	240		125	164
PI3K+	time_stop	43 (30, 55)		45 (31, 56)	38 (26, 56)
PI3K+	n_trt	67 (51, 114)		73 (54, 134)	67 (52, 118)
PI3K+	n_control	141 (87, 211)		154 (90, 207)	120 (70, 207)
PI3K+	post_p	0.05 (0, 0.14)		0.05 (0.01, 0.16)	0.06 (0.01, 0.19)
PI3K+	order	3 (1, 6)		3 (1, 7)	2 (1, 6)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC1	time	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)
all	TC1	n	37 (37, 37)	4 (4, 4)	0 (0, 0)	4 (4, 4)	3 (3, 3)	3 (3, 3)	2 (2, 2)	2 (2, 2)	0 (0, 0)	0 (0, 0)	3 (3, 3)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.51 (0.51, 0.51)	0.55 (0.55, 0.55)	NA (NA, NA)	0.55 (0.55, 0.55)	0.55 (0.55, 0.55)	0.51 (0.51, 0.51)	0.52 (0.52, 0.52)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.005 (0.005, 0.005)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	330	330	330	330	330	330	330	330	330	330	330	330	330	330	330	330
all	TC2	time	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)	29 (13, 50)
all	TC2	n	71 (24, 161)	10 (3, 26)	4 (1, 8)	19 (7, 39)	26 (13, 52)	14 (6, 30)	15 (7, 29)	10 (4, 19)	10 (3, 25)	0 (0, 0)	7 (2, 18)	1 (0, 4)	0 (0, 1)	2 (0, 5)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.9 (0.59, 1)	0.62 (0.51, 0.93)	0.54 (0.5, 0.68)	0.67 (0.52, 0.96)	0.72 (0.53, 0.98)	0.66 (0.52, 0.95)	0.62 (0.52, 0.92)	0.59 (0.51, 0.85)	0.62 (0.52, 0.91)	NA (NA, NA)	0.58 (0.51, 0.86)	0.53 (0.51, 0.6)	0.52 (0.51, 0.56)	0.54 (0.51, 0.64)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.008 (0, 0.012)	0.005 (0, 0.015)	0 (0, 0.016)	0.008 (0, 0.015)	0.008 (0, 0.014)	0.006 (0, 0.015)	0.008 (0, 0.014)	0.006 (0, 0.016)	0.004 (0, 0.014)	NA (NA, NA)	0 (0, 0.015)	0 (0, 0.018)	0 (0, 0)	0 (0, 0.016)	0 (0, 0)	0 (0, 0.018)
all	TC3	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC3	time	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)
all	TC3	n	17 (13, 27)	1 (0, 3)	2 (0, 3)	6 (4, 9)	6 (3, 11)	5 (3, 7)	4 (2, 5)	5 (3, 7)	8 (6, 15)	0 (0, 0)	8 (2, 9)	2 (1, 3)	0 (0, 1)	2 (1, 2)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.61 (0.53, 0.73)	0.57 (0.57, 0.57)	0.51 (0.51, 0.51)	0.55 (0.54, 0.56)	0.52 (0.51, 0.54)	0.53 (0.51, 0.55)	0.53 (0.51, 0.56)	0.53 (0.52, 0.57)	0.58 (0.52, 0.63)	NA (NA, NA)	0.52 (0.52, 0.57)	0.53 (0.53, 0.53)	0.5 (0.5, 0.5)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.005 (0, 0.014)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.006)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.009)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
all	TC4	time	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)	16 (12, 30)
all	TC4	n	13 (9, 53)	7 (6, 18)	1 (0, 5)	11 (9, 13)	9 (5, 31)	13 (8, 30)	5 (2, 13)	6 (3, 19)	4 (2, 14)	0 (0, 0)	4 (2, 6)	1 (1, 4)	0 (0, 1)	2 (2, 3)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.54 (0.51, 0.68)	0.56 (0.52, 0.78)	0.54 (0.52, 0.61)	0.57 (0.56, 0.62)	0.55 (0.53, 0.58)	0.54 (0.52, 0.72)	0.54 (0.51, 0.58)	0.57 (0.53, 0.64)	0.55 (0.53, 0.56)	NA (NA, NA)	0.56 (0.51, 0.65)	0.54 (0.52, 0.55)	NA (NA, NA)	0.52 (0.52, 0.54)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.012 (0.005, 0.015)	0 (0, 0.011)	0 (0, 0.006)	0.011 (0, 0.014)	0 (0, 0.019)	0.009 (0, 0.012)	0 (0, 0.008)	0 (0, 0.011)	0 (0, 0.013)	NA (NA, NA)	0 (0, 0.02)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									66	66	66	66	66	66	66	66
HRD+	TC2	time									52 (44, 58)	52 (44, 58)	52 (44, 58)	52 (44, 58)	52 (44, 58)	52 (44, 58)	52 (44, 58)	52 (44, 58)
HRD+	TC2	n									29 (18, 37)	0 (0, 0)	18 (11, 26)	3 (1, 6)	1 (0, 2)	4 (1, 7)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.93 (0.75, 0.99)	NA (NA, NA)	0.88 (0.72, 0.96)	0.57 (0.51, 0.74)	0.53 (0.51, 0.56)	0.59 (0.51, 0.83)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.008 (0.004, 0.012)	0 (0, 0)	0.007 (0.002, 0.013)	0.007 (0, 0.027)	0 (0, 0.045)	0 (0, 0.019)	0 (0, 0)	0 (0, 0.029)
HRD+	TC3	count									6	6	6	6	6	6	6	6
HRD+	TC3	time									46 (42, 53)	46 (42, 53)	46 (42, 53)	46 (42, 53)	46 (42, 53)	46 (42, 53)	46 (42, 53)	46 (42, 53)
HRD+	TC3	n									26 (17, 33)	0 (0, 0)	20 (14, 25)	2 (2, 6)	0 (0, 2)	6 (2, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.81 (0.73, 0.89)	NA (NA, NA)	0.78 (0.72, 0.88)	0.52 (0.51, 0.59)	0.52 (0.5, 0.53)	0.57 (0.52, 0.62)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.01 (0.004, 0.015)	NA (NA, NA)	0.012 (0.008, 0.015)	0 (0, 0.026)	0.022 (0.004, 0.029)	0.007 (0.003, 0.019)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	count									11	11	11	11	11	11	11	11
HRD+	TC4	time									47 (40, 55)	47 (40, 55)	47 (40, 55)	47 (40, 55)	47 (40, 55)	47 (40, 55)	47 (40, 55)	47 (40, 55)
HRD+	TC4	n									24 (20, 33)	0 (0, 0)	16 (13, 22)	4 (3, 7)	0 (0, 1)	5 (1, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.74 (0.71, 0.87)	NA (NA, NA)	0.78 (0.72, 0.98)	0.54 (0.51, 0.6)	0.54 (0.53, 0.54)	0.57 (0.51, 0.7)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.014 (0.006, 0.018)	NA (NA, NA)	0.009 (0.006, 0.012)	0.011 (0, 0.016)	0 (0, 0)	0.009 (0, 0.025)	NA (NA, NA)	0 (0, 0)
TP53+	TC1	count					2	2	2	2					2	2	2	2
TP53+	TC1	time					28 (23, 34)	28 (23, 34)	28 (23, 34)	28 (23, 34)					28 (23, 34)	28 (23, 34)	28 (23, 34)	28 (23, 34)
TP53+	TC1	n					24 (22, 26)	18 (16, 21)	10 (8, 12)	6 (5, 6)					0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)
TP53+	TC1	post_p					0.8 (0.79, 0.81)	0.8 (0.79, 0.81)	0.66 (0.61, 0.71)	0.59 (0.58, 0.6)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.009 (0.006, 0.012)	0.006 (0.001, 0.01)	0.002 (0, 0.004)	0.007 (0.001, 0.012)					NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)
TP53+	TC2	count					267	267	267	267					267	267	267	267
TP53+	TC2	time					39 (28, 54)	39 (28, 54)	39 (28, 54)	39 (28, 54)					39 (28, 54)	39 (28, 54)	39 (28, 54)	39 (28, 54)
TP53+	TC2	n					34 (20, 61)	20 (9, 35)	19 (10, 33)	12 (6, 23)					0 (0, 1)	2 (0, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.85 (0.72, 0.99)	0.8 (0.67, 0.98)	0.76 (0.62, 0.96)	0.73 (0.54, 0.91)					0.53 (0.5, 0.57)	0.55 (0.51, 0.67)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.009 (0.004, 0.013)	0.008 (0.002, 0.014)	0.009 (0.003, 0.014)	0.008 (0, 0.016)					0 (0, 0.026)	0 (0, 0.019)	NA (NA, NA)	0 (0, 0.025)
TP53+	TC3	count					3	3	3	3					3	3	3	3
TP53+	TC3	time					37 (31, 39)	37 (31, 39)	37 (31, 39)	37 (31, 39)					37 (31, 39)	37 (31, 39)	37 (31, 39)	37 (31, 39)
TP53+	TC3	n					15 (13, 27)	22 (15, 26)	8 (6, 22)	9 (8, 10)					1 (1, 2)	5 (3, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.73 (0.71, 0.75)	0.81 (0.73, 0.85)	0.63 (0.54, 0.78)	0.52 (0.51, 0.6)					0.5 (0.5, 0.5)	0.57 (0.52, 0.69)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.013 (0.011, 0.015)	0.009 (0.008, 0.012)	0.01 (0.008, 0.016)	0.016 (0.003, 0.02)					0 (0, 0.023)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					4	4	4	4					4	4	4	4
TP53+	TC4	time					26 (23, 50)	26 (23, 50)	26 (23, 50)	26 (23, 50)					26 (23, 50)	26 (23, 50)	26 (23, 50)	26 (23, 50)
TP53+	TC4	n					26 (19, 66)	22 (15, 39)	10 (10, 36)	8 (7, 34)					0 (0, 2)	4 (3, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.78 (0.73, 0.82)	0.78 (0.71, 0.86)	0.6 (0.56, 0.7)	0.57 (0.54, 0.81)					0.5 (0.5, 0.5)	0.52 (0.52, 0.62)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.006 (0.005, 0.011)	0.009 (0.002, 0.015)	0.004 (0, 0.012)	0.007 (0, 0.016)					0 (0, 0)	0.014 (0.002, 0.033)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			183	183			183	183			183	183			183	183
TEfus+	TC2	time			39 (26, 56)	39 (26, 56)			39 (26, 56)	39 (26, 56)			39 (26, 56)	39 (26, 56)			39 (26, 56)	39 (26, 56)
TEfus+	TC2	n			5 (2, 9)	26 (16, 44)			20 (10, 31)	13 (6, 22)			10 (5, 20)	2 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.57 (0.51, 0.74)	0.85 (0.72, 0.98)			0.78 (0.7, 0.96)	0.74 (0.56, 0.92)			0.72 (0.54, 0.92)	0.55 (0.51, 0.64)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.008 (0, 0.018)	0.008 (0.003, 0.014)			0.009 (0.003, 0.014)	0.009 (0.001, 0.016)			0.007 (0, 0.016)	0 (0, 0.017)			NA (NA, NA)	0.018 (0, 0.133)
TEfus+	TC3	count			1	1			1	1			1	1			1	1
TEfus+	TC3	time			39 (39, 39)	39 (39, 39)			39 (39, 39)	39 (39, 39)			39 (39, 39)	39 (39, 39)			39 (39, 39)	39 (39, 39)
TEfus+	TC3	n			4 (4, 4)	45 (45, 45)			28 (28, 28)	22 (22, 22)			29 (29, 29)	6 (6, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.51 (0.51, 0.51)	0.73 (0.73, 0.73)			0.72 (0.72, 0.72)	0.76 (0.76, 0.76)			0.76 (0.76, 0.76)	0.55 (0.55, 0.55)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.015 (0.015, 0.015)	0.01 (0.01, 0.01)			0.015 (0.015, 0.015)	0.011 (0.011, 0.011)			0.014 (0.014, 0.014)	0.014 (0.014, 0.014)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			3	3			3	3			3	3			3	3
TEfus+	TC4	time			35 (33, 43)	35 (33, 43)			35 (33, 43)	35 (33, 43)			35 (33, 43)	35 (33, 43)			35 (33, 43)	35 (33, 43)
TEfus+	TC4	n			4 (3, 7)	26 (19, 40)			20 (12, 28)	17 (11, 17)			10 (8, 20)	5 (2, 7)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.61 (0.52, 0.67)	0.73 (0.71, 0.79)			0.77 (0.66, 0.94)	0.7 (0.65, 0.71)			0.85 (0.67, 0.88)	0.57 (0.53, 0.61)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.008 (0.002, 0.012)	0.01 (0.008, 0.016)			0.012 (0.002, 0.013)	0.017 (0.013, 0.018)			0.009 (0.007, 0.009)	0 (0, 0.016)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		1		1		1		1		1		1		1		1
PI3K+	TC1	time		28 (28, 28)		28 (28, 28)		28 (28, 28)		28 (28, 28)		28 (28, 28)		28 (28, 28)		28 (28, 28)		28 (28, 28)
PI3K+	TC1	n		9 (9, 9)		21 (21, 21)		15 (15, 15)		6 (6, 6)		0 (0, 0)		2 (2, 2)		1 (1, 1)		0 (0, 0)
PI3K+	TC1	post_p		0.61 (0.61, 0.61)		0.72 (0.72, 0.72)		0.72 (0.72, 0.72)		0.5 (0.5, 0.5)		NA (NA, NA)		0.55 (0.55, 0.55)		0.54 (0.54, 0.54)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.009 (0.009, 0.009)		0.009 (0.009, 0.009)		0 (0, 0)		0.016 (0.016, 0.016)		NA (NA, NA)		0 (0, 0)		0 (0, 0)		NA (NA, NA)
PI3K+	TC2	count		194		194		194		194		194		194		194		194
PI3K+	TC2	time		38 (25, 54)		38 (25, 54)		38 (25, 54)		38 (25, 54)		38 (25, 54)		38 (25, 54)		38 (25, 54)		38 (25, 54)
PI3K+	TC2	n		16 (7, 30)		26 (16, 49)		21 (11, 35)		13 (7, 23)		0 (0, 0)		2 (0, 5)		2 (0, 5)		0 (0, 0)
PI3K+	TC2	post_p		0.78 (0.57, 0.96)		0.84 (0.72, 0.98)		0.81 (0.71, 0.98)		0.74 (0.53, 0.91)		NA (NA, NA)		0.54 (0.51, 0.62)		0.55 (0.51, 0.65)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.008 (0, 0.014)		0.008 (0.003, 0.014)		0.008 (0, 0.013)		0.009 (0, 0.016)		NA (NA, NA)		0 (0, 0.019)		0 (0, 0.019)		0.018 (0.004, 0.033)
PI3K+	TC3	count		3		3		3		3		3		3		3		3
PI3K+	TC3	time		26 (24, 27)		26 (24, 27)		26 (24, 27)		26 (24, 27)		26 (24, 27)		26 (24, 27)		26 (24, 27)		26 (24, 27)
PI3K+	TC3	n		10 (9, 13)		23 (15, 23)		15 (11, 17)		10 (8, 14)		0 (0, 0)		1 (0, 2)		0 (0, 3)		0 (0, 0)
PI3K+	TC3	post_p		0.7 (0.6, 0.75)		0.8 (0.73, 0.81)		0.76 (0.74, 0.77)		0.58 (0.54, 0.68)		NA (NA, NA)		0.53 (0.52, 0.53)		0.52 (0.52, 0.52)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.007 (0.001, 0.01)		0.005 (0.005, 0.006)		0 (0, 0.005)		0.008 (0.002, 0.011)		NA (NA, NA)		0 (0, 0)		0.03 (0.03, 0.03)		NA (NA, NA)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	103	103	103	103	103	103	103	103	103	103	103	103	103	103	103	103
all	TC1	time	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)	46 (34, 57)
all	TC1	n	35 (23, 61)	13 (7, 27)	5 (2, 8)	17 (9, 41)	17 (9, 47)	15 (9, 34)	13 (7, 23)	10 (5, 21)	12 (6, 21)	0 (0, 0)	8 (4, 20)	2 (0, 5)	0 (0, 1)	3 (0, 6)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.11 (0.01, 0.31)	0.24 (0.07, 0.45)	0.41 (0.22, 0.49)	0.18 (0.05, 0.45)	0.18 (0.04, 0.42)	0.21 (0.07, 0.45)	0.24 (0.05, 0.42)	0.31 (0.07, 0.46)	0.25 (0.07, 0.45)	NA (NA, NA)	0.31 (0.09, 0.46)	0.45 (0.34, 0.49)	0.47 (0.43, 0.5)	0.42 (0.31, 0.49)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.027 (0.02, 0.035)	0.027 (0.019, 0.04)	0.027 (0.017, 0.067)	0.026 (0.018, 0.04)	0.026 (0.017, 0.043)	0.027 (0.019, 0.038)	0.026 (0.018, 0.042)	0.027 (0.018, 0.045)	0.029 (0.02, 0.051)	0 (0, 0)	0.029 (0.017, 0.051)	0.037 (0.01, 0.078)	0.017 (0, 0.145)	0.031 (0.012, 0.109)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26
all	TC3	time	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)	54 (36, 59)
all	TC3	n	42 (22, 138)	12 (8, 28)	6 (2, 8)	20 (8, 42)	20 (13, 54)	13 (7, 30)	11 (8, 30)	11 (6, 22)	16 (10, 26)	0 (0, 0)	12 (8, 22)	2 (1, 6)	0 (0, 2)	4 (2, 7)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.19 (0.05, 0.44)	0.3 (0.12, 0.46)	0.33 (0.15, 0.47)	0.27 (0.09, 0.46)	0.32 (0.07, 0.45)	0.31 (0.12, 0.45)	0.32 (0.14, 0.48)	0.26 (0.05, 0.44)	0.26 (0.07, 0.43)	NA (NA, NA)	0.3 (0.12, 0.48)	0.42 (0.22, 0.48)	0.44 (0.38, 0.48)	0.4 (0.32, 0.47)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.023 (0.018, 0.029)	0.023 (0.017, 0.03)	0.029 (0.022, 0.101)	0.023 (0.016, 0.04)	0.022 (0.017, 0.038)	0.025 (0.019, 0.033)	0.023 (0.016, 0.033)	0.025 (0.019, 0.041)	0.025 (0.02, 0.034)	NA (NA, NA)	0.024 (0.018, 0.036)	0.038 (0.017, 0.083)	0.062 (0.013, 0.141)	0.022 (0.014, 0.048)	NA (NA, NA)	0 (0, 0)
all	TC4	count	39	39	39	39	39	39	39	39	39	39	39	39	39	39	39	39
all	TC4	time	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)	47 (27, 59)
all	TC4	n	37 (21, 100)	14 (7, 24)	4 (1, 7)	14 (8, 21)	16 (9, 40)	11 (7, 26)	11 (5, 20)	9 (5, 15)	10 (4, 23)	0 (0, 0)	7 (3, 22)	2 (0, 6)	0 (0, 1)	3 (1, 6)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.19 (0.04, 0.42)	0.34 (0.12, 0.48)	0.42 (0.3, 0.48)	0.26 (0.13, 0.42)	0.31 (0.14, 0.48)	0.27 (0.07, 0.46)	0.32 (0.08, 0.45)	0.34 (0.17, 0.43)	0.35 (0.11, 0.49)	NA (NA, NA)	0.41 (0.16, 0.48)	0.43 (0.37, 0.49)	0.48 (0.48, 0.48)	0.41 (0.29, 0.49)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.022 (0.017, 0.031)	0.024 (0.016, 0.036)	0.03 (0.017, 0.079)	0.025 (0.018, 0.038)	0.022 (0.018, 0.033)	0.025 (0.019, 0.049)	0.024 (0.017, 0.054)	0.024 (0.016, 0.039)	0.025 (0.015, 0.052)	NA (NA, NA)	0.024 (0.016, 0.053)	0.028 (0.009, 0.064)	0.094 (0, 0.201)	0.029 (0.012, 0.073)	NA (NA, NA)	0 (0, 0)
HRD+	TC1	count									28	28	28	28	28	28	28	28
HRD+	TC1	time									54 (49, 58)	54 (49, 58)	54 (49, 58)	54 (49, 58)	54 (49, 58)	54 (49, 58)	54 (49, 58)	54 (49, 58)
HRD+	TC1	n									25 (12, 37)	0 (0, 0)	20 (9, 32)	3 (2, 7)	0 (0, 2)	4 (0, 7)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.28 (0.12, 0.46)	NA (NA, NA)	0.25 (0.06, 0.48)	0.45 (0.32, 0.49)	0.46 (0.44, 0.47)	0.39 (0.24, 0.48)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.024 (0.018, 0.032)	NA (NA, NA)	0.024 (0.018, 0.04)	0.029 (0.017, 0.06)	0.04 (0.025, 0.066)	0.027 (0.018, 0.045)	NA (NA, NA)	0.021 (0.021, 0.021)
HRD+	TC3	count									37	37	37	37	37	37	37	37
HRD+	TC3	time									52 (41, 59)	52 (41, 59)	52 (41, 59)	52 (41, 59)	52 (41, 59)	52 (41, 59)	52 (41, 59)	52 (41, 59)
HRD+	TC3	n									25 (15, 38)	0 (0, 0)	18 (9, 32)	4 (2, 7)	0 (0, 2)	4 (2, 9)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.28 (0.09, 0.48)	NA (NA, NA)	0.38 (0.08, 0.47)	0.44 (0.34, 0.49)	0.46 (0.45, 0.48)	0.38 (0.22, 0.47)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.022 (0.017, 0.033)	0 (0, 0)	0.023 (0.018, 0.033)	0.03 (0.013, 0.076)	0.041 (0, 0.131)	0.031 (0.016, 0.067)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	count									31	31	31	31	31	31	31	31
HRD+	TC4	time									55 (45, 59)	55 (45, 59)	55 (45, 59)	55 (45, 59)	55 (45, 59)	55 (45, 59)	55 (45, 59)	55 (45, 59)
HRD+	TC4	n									25 (15, 39)	0 (0, 0)	18 (7, 28)	4 (1, 7)	0 (0, 2)	3 (1, 7)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.32 (0.12, 0.46)	NA (NA, NA)	0.28 (0.17, 0.45)	0.43 (0.34, 0.48)	0.47 (0.46, 0.49)	0.39 (0.27, 0.47)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.022 (0.018, 0.028)	NA (NA, NA)	0.023 (0.016, 0.032)	0.032 (0.018, 0.094)	0.034 (0.002, 0.087)	0.031 (0.016, 0.098)	0 (0, 0)	0 (0, 0)
TP53+	TC1	count					294	294	294	294					294	294	294	294
TP53+	TC1	time					42 (29, 56)	42 (29, 56)	42 (29, 56)	42 (29, 56)					42 (29, 56)	42 (29, 56)	42 (29, 56)	42 (29, 56)
TP53+	TC1	n					20 (10, 45)	15 (9, 34)	14 (7, 29)	11 (6, 25)					0 (0, 2)	3 (1, 7)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.23 (0.04, 0.47)	0.3 (0.08, 0.47)	0.32 (0.07, 0.47)	0.35 (0.12, 0.47)					0.47 (0.43, 0.5)	0.44 (0.3, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.024 (0.017, 0.039)	0.024 (0.016, 0.04)	0.023 (0.016, 0.044)	0.024 (0.016, 0.044)					0 (0, 0.133)	0.029 (0, 0.091)	0.046 (0.046, 0.046)	0.021 (0, 0.048)
TP53+	TC2	count					1	1	1	1					1	1	1	1
TP53+	TC2	time					27 (27, 27)	27 (27, 27)	27 (27, 27)	27 (27, 27)					27 (27, 27)	27 (27, 27)	27 (27, 27)	27 (27, 27)
TP53+	TC2	n					25 (25, 25)	25 (25, 25)	10 (10, 10)	8 (8, 8)					2 (2, 2)	1 (1, 1)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.27 (0.27, 0.27)	0.5 (0.5, 0.5)	0.3 (0.3, 0.3)	0.46 (0.46, 0.46)					NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.022 (0.022, 0.022)	0.009 (0.009, 0.009)	0.026 (0.026, 0.026)	0.031 (0.031, 0.031)					0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					159	159	159	159					159	159	159	159
TP53+	TC3	time					40 (28, 56)	40 (28, 56)	40 (28, 56)	40 (28, 56)					40 (28, 56)	40 (28, 56)	40 (28, 56)	40 (28, 56)
TP53+	TC3	n					22 (13, 48)	16 (8, 39)	14 (8, 32)	12 (6, 23)					0 (0, 2)	4 (2, 8)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.32 (0.06, 0.47)	0.33 (0.12, 0.48)	0.34 (0.16, 0.48)	0.37 (0.13, 0.48)					0.45 (0.41, 0.49)	0.44 (0.31, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.021 (0.016, 0.033)	0.022 (0.016, 0.036)	0.022 (0.015, 0.037)	0.023 (0.016, 0.043)					0.029 (0, 0.178)	0.028 (0.014, 0.064)	NA (NA, NA)	0.05 (0.01, 0.091)
TP53+	TC4	count					182	182	182	182					182	182	182	182
TP53+	TC4	time					39 (27, 56)	39 (27, 56)	39 (27, 56)	39 (27, 56)					39 (27, 56)	39 (27, 56)	39 (27, 56)	39 (27, 56)
TP53+	TC4	n					21 (11, 52)	16 (10, 31)	13 (7, 30)	12 (7, 22)					0 (0, 1)	3 (1, 7)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.35 (0.09, 0.48)	0.32 (0.1, 0.48)	0.38 (0.12, 0.48)	0.36 (0.13, 0.47)					0.47 (0.43, 0.49)	0.44 (0.32, 0.5)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.021 (0.016, 0.04)	0.023 (0.016, 0.034)	0.022 (0.015, 0.039)	0.023 (0.015, 0.043)					0 (0, 0.105)	0.027 (0, 0.068)	0 (0, 0)	0 (0, 0.072)
TEfus+	TC1	count			191	191			191	191			191	191			191	191
TEfus+	TC1	time			45 (33, 57)	45 (33, 57)			45 (33, 57)	45 (33, 57)			45 (33, 57)	45 (33, 57)			45 (33, 57)	45 (33, 57)
TEfus+	TC1	n			5 (2, 10)	18 (9, 44)			14 (8, 30)	12 (6, 29)			9 (5, 18)	3 (0, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.41 (0.24, 0.49)	0.27 (0.06, 0.44)			0.26 (0.08, 0.46)	0.3 (0.08, 0.48)			0.31 (0.1, 0.47)	0.44 (0.33, 0.49)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.029 (0.017, 0.061)	0.024 (0.018, 0.036)			0.025 (0.017, 0.042)	0.025 (0.017, 0.042)			0.029 (0.017, 0.048)	0.035 (0.011, 0.085)			NA (NA, NA)	0.03 (0.006, 0.064)
TEfus+	TC2	count			1	1			1	1			1	1			1	1
TEfus+	TC2	time			32 (32, 32)	32 (32, 32)			32 (32, 32)	32 (32, 32)			32 (32, 32)	32 (32, 32)			32 (32, 32)	32 (32, 32)
TEfus+	TC2	n			4 (4, 4)	13 (13, 13)			26 (26, 26)	11 (11, 11)			4 (4, 4)	2 (2, 2)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.46 (0.46, 0.46)	0.2 (0.2, 0.2)			0.49 (0.49, 0.49)	0.45 (0.45, 0.45)			0.4 (0.4, 0.4)	0.45 (0.45, 0.45)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.008 (0.008, 0.008)	0.025 (0.025, 0.025)			0.014 (0.014, 0.014)	0.011 (0.011, 0.011)			0.047 (0.047, 0.047)	0.037 (0.037, 0.037)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			129	129			129	129			129	129			129	129
TEfus+	TC3	time			45 (31, 58)	45 (31, 58)			45 (31, 58)	45 (31, 58)			45 (31, 58)	45 (31, 58)			45 (31, 58)	45 (31, 58)
TEfus+	TC3	n			5 (3, 10)	20 (9, 45)			14 (8, 31)	12 (6, 29)			11 (6, 19)	3 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.42 (0.29, 0.49)	0.3 (0.07, 0.46)			0.33 (0.1, 0.46)	0.34 (0.12, 0.48)			0.34 (0.14, 0.48)	0.44 (0.32, 0.49)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.028 (0.014, 0.055)	0.021 (0.015, 0.038)			0.024 (0.015, 0.038)	0.023 (0.014, 0.039)			0.024 (0.015, 0.038)	0.028 (0.01, 0.078)			NA (NA, NA)	0 (0, 0)
TEfus+	TC4	count			107	107			107	107			107	107			107	107
TEfus+	TC4	time			45 (33, 57)	45 (33, 57)			45 (33, 57)	45 (33, 57)			45 (33, 57)	45 (33, 57)			45 (33, 57)	45 (33, 57)
TEfus+	TC4	n			5 (2, 9)	19 (12, 47)			14 (7, 27)	12 (6, 26)			10 (5, 21)	3 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.4 (0.27, 0.49)	0.28 (0.08, 0.48)			0.34 (0.08, 0.47)	0.33 (0.09, 0.48)			0.33 (0.1, 0.47)	0.45 (0.35, 0.5)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.029 (0.015, 0.092)	0.022 (0.016, 0.033)			0.024 (0.018, 0.044)	0.023 (0.015, 0.037)			0.027 (0.017, 0.05)	0.027 (0.01, 0.098)			0.035 (0.007, 0.064)	0 (0, 0)
PI3K+	TC1	count		240		240		240		240		240		240		240		240
PI3K+	TC1	time		43 (30, 55)		43 (30, 55)		43 (30, 55)		43 (30, 55)		43 (30, 55)		43 (30, 55)		43 (30, 55)		43 (30, 55)
PI3K+	TC1	n		14 (8, 28)		19 (10, 41)		15 (8, 33)		11 (6, 27)		0 (0, 0)		3 (0, 5)		3 (1, 7)		0 (0, 0)
PI3K+	TC1	post_p		0.33 (0.09, 0.48)		0.25 (0.06, 0.45)		0.28 (0.07, 0.46)		0.31 (0.1, 0.48)		NA (NA, NA)		0.45 (0.35, 0.49)		0.45 (0.3, 0.49)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.024 (0.016, 0.039)		0.025 (0.017, 0.04)		0.025 (0.017, 0.038)		0.025 (0.017, 0.045)		0 (0, 0)		0.034 (0, 0.083)		0.029 (0.01, 0.094)		0.037 (0.007, 0.058)
PI3K+	TC3	count		125		125		125		125		125		125		125		125
PI3K+	TC3	time		45 (31, 56)		45 (31, 56)		45 (31, 56)		45 (31, 56)		45 (31, 56)		45 (31, 56)		45 (31, 56)		45 (31, 56)
PI3K+	TC3	n		16 (8, 31)		20 (9, 47)		15 (8, 35)		12 (6, 23)		0 (0, 0)		3 (1, 6)		4 (2, 7)		0 (0, 0)
PI3K+	TC3	post_p		0.36 (0.11, 0.48)		0.32 (0.05, 0.46)		0.31 (0.09, 0.48)		0.34 (0.08, 0.47)		NA (NA, NA)		0.45 (0.36, 0.49)		0.42 (0.26, 0.49)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.022 (0.016, 0.039)		0.022 (0.016, 0.036)		0.022 (0.017, 0.037)		0.024 (0.017, 0.043)		0 (0, 0)		0.028 (0.009, 0.081)		0.027 (0.012, 0.069)		NA (NA, NA)
PI3K+	TC4	count		164		164		164		164		164		164		164		164
PI3K+	TC4	time		38 (26, 56)		38 (26, 56)		38 (26, 56)		38 (26, 56)		38 (26, 56)		38 (26, 56)		38 (26, 56)		38 (26, 56)
PI3K+	TC4	n		14 (8, 30)		18 (10, 43)		15 (9, 32)		12 (6, 20)		0 (0, 0)		3 (1, 6)		3 (1, 6)		0 (0, 0)
PI3K+	TC4	post_p		0.33 (0.1, 0.47)		0.29 (0.06, 0.47)		0.28 (0.06, 0.46)		0.38 (0.11, 0.48)		NA (NA, NA)		0.46 (0.37, 0.49)		0.44 (0.35, 0.49)		NA (NA, NA)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.023 (0.015, 0.041)		0.022 (0.016, 0.033)		0.024 (0.015, 0.036)		0.023 (0.014, 0.041)		NA (NA, NA)		0.026 (0, 0.071)		0.029 (0, 0.089)		0 (0, 0)