Setting description

TC2 more effective in all the biomarker signatures

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4
all param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
all summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
all effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
HRD+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
HRD+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
HRD+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
TP53+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
TP53+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
TEfus+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
TEfus+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
PI3K+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
PI3K+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
PI3K+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4
—- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
—- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
—+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–+- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
–+- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
–++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+– summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
-+– effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+-+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
-+-+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-++- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
-++- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
-+++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+— summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
+— effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+–+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
+–+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+-+- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
+-+- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+-++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
+-++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
++– summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
++– effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
++-+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
++-+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+++- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
+++- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
++++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
++++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4
all 1 330 4 5
HRD+ 0 66 6 11
TP53+ 2 267 3 4
TEfus+ 0 183 1 3
PI3K+ 1 194 3 0
TC1 TC2 TC3 TC4
all 0.002 0.660 0.008 0.010
HRD+ 0.000 0.132 0.012 0.022
TP53+ 0.004 0.534 0.006 0.008
TEfus+ 0.000 0.366 0.002 0.006
PI3K+ 0.002 0.388 0.006 0.000
futility (counts and proportions):
TC1 TC2 TC3 TC4
all 103 0 26 39
HRD+ 28 0 37 31
TP53+ 294 1 159 182
TEfus+ 191 1 129 107
PI3K+ 240 0 125 164
TC1 TC2 TC3 TC4
all 0.206 0.000 0.052 0.078
HRD+ 0.056 0.000 0.074 0.062
TP53+ 0.588 0.002 0.318 0.364
TEfus+ 0.382 0.002 0.258 0.214
PI3K+ 0.480 0.000 0.250 0.328
max sample size (counts and proportions):
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0


Operating characteristics

Characteristics Overall TC1 TC2 TC3 TC4
Error signature 0.334 0.008 0.272 0.034 0.044
Error subgroup 0.086 0.008 0.000 0.034 0.044
Power signature 0.660 0.000 0.660 0.000 0.000
Power subgroup 0.932 0.000 0.932 0.000 0.000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4
all graduation 0 1 330 4 5
all futility 0 103 0 26 39
all max_n 0 0 0 0 0
all n 658 (606, 706) 209 (151, 304) 301 (94, 503) 298 (194, 443) 290 (176, 438)
all n_unique 658 (606, 706) 209 (151, 304) 301 (94, 503) 298 (194, 443) 290 (176, 438)
all time_trial 60 (60, 60) 60 (46, 60) 42 (14, 60) 60 (60, 60) 60 (60, 60)
all time_stop NA (NA, NA) 46 (34, 57) 29 (13, 50) 50 (18, 59) 38 (17, 58)
all post_p NA (NA, NA) 0 (0, 0.03) 1 (1, 1) 0.05 (0, 0.35) 0.05 (0, 0.35)
all rate 0.018 (0.016, 0.019) 0.025 (0.023, 0.029) 0.011 (0.009, 0.012) 0.021 (0.019, 0.024) 0.021 (0.019, 0.024)
HRD+ graduation 0 0 66 6 11
HRD+ futility 0 28 0 37 31
HRD+ max_n 0 0 0 0 0
HRD+ n 89 (74, 103) 38 (23, 57) 34 (8, 58) 47 (30, 66) 48 (26, 71)
HRD+ n_unique 89 (74, 103) 38 (23, 57) 34 (8, 58) 47 (30, 66) 48 (26, 71)
HRD+ time_trial 60 (60, 60) 60 (60, 60) 60 (56, 60) 60 (60, 60) 60 (60, 60)
HRD+ time_stop NA (NA, NA) 54 (49, 58) 52 (44, 58) 51 (42, 59) 52 (43, 58)
HRD+ post_p NA (NA, NA) 0.11 (0.01, 0.51) 0.94 (0.63, 1) 0.19 (0.03, 0.64) 0.28 (0.04, 0.72)
HRD+ rate 0.018 (0.014, 0.022) 0.025 (0.019, 0.034) 0.01 (0.006, 0.016) 0.023 (0.017, 0.03) 0.021 (0.016, 0.028)
TP53+ graduation 0 2 267 3 4
TP53+ futility 0 294 1 159 182
TP53+ max_n 0 0 0 0 0
TP53+ n 240 (211, 267) 78 (50, 135) 91 (40, 172) 116 (55, 183) 106 (52, 184)
TP53+ n_unique 240 (211, 267) 78 (50, 135) 91 (40, 172) 116 (55, 183) 106 (52, 184)
TP53+ time_trial 60 (60, 60) 53 (32, 60) 56 (30, 60) 60 (35, 60) 60 (32, 60)
TP53+ time_stop NA (NA, NA) 42 (28, 56) 39 (27, 54) 40 (28, 56) 39 (27, 56)
TP53+ post_p NA (NA, NA) 0.03 (0, 0.23) 1 (0.95, 1) 0.15 (0.01, 0.58) 0.15 (0.01, 0.59)
TP53+ rate 0.018 (0.015, 0.02) 0.026 (0.021, 0.031) 0.011 (0.009, 0.013) 0.021 (0.017, 0.026) 0.021 (0.018, 0.027)
TEfus+ graduation 0 0 183 1 3
TEfus+ futility 0 191 1 129 107
TEfus+ max_n 0 0 0 0 0
TEfus+ n 204 (178, 232) 78 (50, 124) 75 (30, 147) 103 (57, 156) 98 (53, 152)
TEfus+ n_unique 204 (178, 232) 78 (50, 124) 75 (30, 147) 103 (57, 156) 98 (53, 152)
TEfus+ time_trial 60 (60, 60) 60 (39, 60) 60 (33, 60) 60 (40, 60) 60 (44, 60)
TEfus+ time_stop NA (NA, NA) 45 (33, 57) 39 (26, 56) 44 (31, 58) 45 (33, 57)
TEfus+ post_p NA (NA, NA) 0.04 (0, 0.26) 1 (0.92, 1) 0.15 (0.02, 0.55) 0.16 (0.01, 0.58)
TEfus+ rate 0.017 (0.015, 0.02) 0.025 (0.02, 0.031) 0.011 (0.008, 0.013) 0.021 (0.018, 0.026) 0.021 (0.018, 0.027)
PI3K+ graduation 0 1 194 3 0
PI3K+ futility 0 240 0 125 164
PI3K+ max_n 0 0 0 0 0
PI3K+ n 223 (194, 249) 82 (51, 134) 78 (29, 155) 114 (60, 176) 102 (54, 164)
PI3K+ n_unique 223 (194, 249) 82 (51, 134) 78 (29, 155) 114 (60, 176) 102 (54, 164)
PI3K+ time_trial 60 (60, 60) 60 (34, 60) 60 (30, 60) 60 (41, 60) 60 (33, 60)
PI3K+ time_stop NA (NA, NA) 43 (29, 55) 38 (25, 54) 44 (31, 56) 38 (26, 56)
PI3K+ post_p NA (NA, NA) 0.03 (0, 0.25) 1 (0.91, 1) 0.18 (0.01, 0.6) 0.15 (0.01, 0.55)
PI3K+ rate 0.017 (0.015, 0.02) 0.025 (0.021, 0.031) 0.01 (0.008, 0.013) 0.021 (0.017, 0.026) 0.022 (0.019, 0.027)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4
—- graduation 0 1 330 4 5
—- futility 0 103 0 26 39
—- max_n 0 0 0 0 0
—- n 212 (180, 240) 37 (23, 87) 112 (28, 211) 62 (24, 173) 64 (25, 174)
—- n_unique 212 (180, 240) 37 (23, 87) 112 (28, 211) 62 (24, 173) 64 (25, 174)
—- post_p NA (NA, NA) 0.06 (0, 0.31) 1 (0.92, 1) 0.18 (0.02, 0.63) 0.19 (0.03, 0.62)
—- rate 0.018 (0.015, 0.02) 0.027 (0.022, 0.035) 0.01 (0.008, 0.013) 0.022 (0.017, 0.03) 0.021 (0.017, 0.029)
—+ graduation 0 2 384 7 5
—+ futility 0 254 0 130 174
—+ max_n 0 0 0 0 0
—+ n 46 (36, 56) 15 (8, 35) 15 (4, 40) 23 (9, 45) 18 (8, 41)
—+ n_unique 46 (36, 56) 15 (8, 35) 15 (4, 40) 23 (9, 45) 18 (8, 41)
—+ post_p NA (NA, NA) 0.2 (0.04, 0.57) 0.86 (0.46, 0.98) 0.36 (0.07, 0.76) 0.31 (0.07, 0.66)
—+ rate 0.017 (0.012, 0.023) 0.026 (0.018, 0.042) 0.01 (0.005, 0.019) 0.021 (0.014, 0.034) 0.022 (0.015, 0.037)
–+- graduation 0 1 379 5 8
–+- futility 0 215 1 131 119
–+- max_n 0 0 0 0 0
–+- n 13 (8, 18) 6 (3, 12) 5 (2, 11) 7 (3, 13) 7 (3, 13)
–+- n_unique 13 (8, 18) 6 (3, 12) 5 (2, 11) 7 (3, 13) 7 (3, 13)
–+- post_p NA (NA, NA) 0.39 (0.14, 0.65) 0.66 (0.39, 0.88) 0.42 (0.18, 0.72) 0.46 (0.2, 0.73)
–+- rate 0.018 (0.009, 0.032) 0.026 (0.012, 0.056) 0.01 (0, 0.027) 0.022 (0.009, 0.046) 0.022 (0.009, 0.049)
–++ graduation 0 2 422 6 8
–++ futility 0 313 1 198 217
–++ max_n 0 0 0 0 0
–++ n 68 (55, 82) 20 (10, 49) 24 (9, 56) 30 (11, 62) 24 (12, 60)
–++ n_unique 68 (55, 82) 20 (10, 49) 24 (9, 56) 30 (11, 62) 24 (12, 60)
–++ post_p NA (NA, NA) 0.17 (0.02, 0.52) 0.92 (0.64, 1) 0.3 (0.06, 0.73) 0.27 (0.04, 0.7)
–++ rate 0.017 (0.013, 0.022) 0.026 (0.018, 0.039) 0.011 (0.007, 0.016) 0.021 (0.015, 0.034) 0.023 (0.016, 0.033)
-+– graduation 0 3 413 7 9
-+– futility 0 313 1 162 195
-+– max_n 0 0 0 0 0
-+– n 87 (70, 101) 20 (10, 49) 33 (14, 76) 33 (13, 75) 33 (12, 77)
-+– n_unique 87 (70, 101) 20 (10, 49) 33 (14, 76) 33 (13, 75) 33 (12, 77)
-+– post_p NA (NA, NA) 0.14 (0.01, 0.47) 0.96 (0.73, 1) 0.29 (0.06, 0.7) 0.29 (0.04, 0.75)
-+– rate 0.018 (0.014, 0.022) 0.027 (0.02, 0.04) 0.011 (0.007, 0.016) 0.022 (0.016, 0.032) 0.021 (0.015, 0.032)
-+-+ graduation 0 4 430 8 9
-+-+ futility 0 362 1 217 248
-+-+ max_n 0 0 0 0 0
-+-+ n 56 (42, 69) 16 (9, 40) 19 (7, 43) 25 (9, 52) 21 (10, 51)
-+-+ n_unique 56 (42, 69) 16 (9, 40) 19 (7, 43) 25 (9, 52) 21 (10, 51)
-+-+ post_p NA (NA, NA) 0.19 (0.04, 0.56) 0.9 (0.58, 0.99) 0.33 (0.08, 0.72) 0.29 (0.07, 0.7)
-+-+ rate 0.017 (0.013, 0.023) 0.026 (0.017, 0.04) 0.011 (0.006, 0.017) 0.022 (0.015, 0.034) 0.023 (0.016, 0.034)
-++- graduation 0 3 440 8 10
-++- futility 0 370 1 230 241
-++- max_n 0 0 0 0 0
-++- n 49 (37, 63) 14 (8, 35) 18 (8, 40) 22 (8, 46) 20 (8, 45)
-++- n_unique 49 (37, 63) 14 (8, 35) 18 (8, 40) 22 (8, 46) 20 (8, 45)
-++- post_p NA (NA, NA) 0.21 (0.05, 0.56) 0.89 (0.6, 0.98) 0.32 (0.07, 0.71) 0.32 (0.07, 0.71)
-++- rate 0.017 (0.012, 0.023) 0.026 (0.018, 0.04) 0.011 (0.006, 0.017) 0.022 (0.015, 0.034) 0.022 (0.014, 0.036)
-+++ graduation 0 4 452 8 10
-+++ futility 0 399 1 266 283
-+++ max_n 0 0 0 0 0
-+++ n 37 (27, 48) 12 (6, 32) 12 (5, 24) 17 (7, 37) 15 (7, 37)
-+++ n_unique 37 (27, 48) 12 (6, 32) 12 (5, 24) 17 (7, 37) 15 (7, 37)
-+++ post_p NA (NA, NA) 0.24 (0.05, 0.6) 0.83 (0.47, 0.97) 0.37 (0.09, 0.71) 0.34 (0.09, 0.75)
-+++ rate 0.017 (0.012, 0.024) 0.026 (0.016, 0.044) 0.011 (0.005, 0.019) 0.021 (0.014, 0.036) 0.022 (0.015, 0.037)
+— graduation 0 1 372 10 16
+— futility 0 127 0 59 68
+— max_n 0 0 0 0 0
+— n 42 (33, 52) 14 (7, 32) 14 (3, 34) 18 (10, 35) 20 (9, 39)
+— n_unique 42 (33, 52) 14 (7, 32) 14 (3, 34) 18 (10, 35) 20 (9, 39)
+— post_p NA (NA, NA) 0.23 (0.04, 0.57) 0.84 (0.48, 0.98) 0.31 (0.06, 0.74) 0.37 (0.09, 0.78)
+— rate 0.017 (0.013, 0.025) 0.026 (0.018, 0.045) 0.01 (0.005, 0.02) 0.023 (0.015, 0.036) 0.021 (0.014, 0.035)
+–+ graduation 0 2 411 13 16
+–+ futility 0 267 0 153 189
+–+ max_n 0 0 0 0 0
+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
+–+ rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.013 (0, 0.444) 0.032 (0.032, 0.032)
+-+- graduation 0 1 414 11 19
+-+- futility 0 233 1 155 142
+-+- max_n 0 0 0 0 0
+-+- n 30 (22, 39) 12 (5, 24) 9 (2, 22) 14 (7, 26) 14 (6, 27)
+-+- n_unique 30 (22, 39) 12 (5, 24) 9 (2, 22) 14 (7, 26) 14 (6, 27)
+-+- post_p NA (NA, NA) 0.26 (0.06, 0.66) 0.79 (0.41, 0.96) 0.33 (0.08, 0.7) 0.4 (0.1, 0.77)
+-+- rate 0.018 (0.012, 0.025) 0.027 (0.015, 0.048) 0.01 (0.002, 0.023) 0.023 (0.015, 0.04) 0.021 (0.012, 0.04)
+-++ graduation 0 2 442 12 19
+-++ futility 0 323 1 215 230
+-++ max_n 0 0 0 0 0
+-++ n 6 (3, 10) 3 (1, 7) 2 (0, 5) 4 (1, 8) 4 (1, 8)
+-++ n_unique 6 (3, 10) 3 (1, 7) 2 (0, 5) 4 (1, 8) 4 (1, 8)
+-++ post_p NA (NA, NA) 0.45 (0.26, 0.62) 0.56 (0.41, 0.73) 0.47 (0.27, 0.66) 0.47 (0.29, 0.64)
+-++ rate 0.016 (0, 0.038) 0.028 (0, 0.071) 0.009 (0, 0.038) 0.022 (0.005, 0.065) 0.023 (0.005, 0.056)
++– graduation 0 3 434 12 20
++– futility 0 325 1 185 206
++– max_n 0 0 0 0 0
++– n 1 (0, 3) 1 (0, 2) 0 (0, 1) 1 (0, 2) 1 (0, 2)
++– n_unique 1 (0, 3) 1 (0, 2) 0 (0, 1) 1 (0, 2) 1 (0, 2)
++– post_p NA (NA, NA) 0.49 (0.42, 0.56) 0.53 (0.44, 0.57) 0.49 (0.43, 0.56) 0.5 (0.44, 0.55)
++– rate 0.008 (0, 0.075) 0.022 (0, 0.126) 0 (0, 0.045) 0.019 (0, 0.126) 0.018 (0, 0.095)
++-+ graduation 0 4 449 13 20
++-+ futility 0 369 1 233 255
++-+ max_n 0 0 0 0 0
++-+ n 8 (4, 13) 4 (1, 8) 2 (0, 6) 5 (2, 10) 4 (2, 11)
++-+ n_unique 8 (4, 13) 4 (1, 8) 2 (0, 6) 5 (2, 10) 4 (2, 11)
++-+ post_p NA (NA, NA) 0.43 (0.22, 0.64) 0.59 (0.4, 0.82) 0.45 (0.25, 0.72) 0.46 (0.24, 0.68)
++-+ rate 0.017 (0.006, 0.035) 0.026 (0.009, 0.068) 0.009 (0, 0.035) 0.023 (0.009, 0.055) 0.023 (0.009, 0.061)
+++- graduation 0 3 456 13 21
+++- futility 0 382 1 248 251
+++- max_n 0 0 0 0 0
+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
+++- rate 0 (0, 0) 0.046 (0.046, 0.046) 0 (0, 0.037) 0.006 (0, 0.038) 0 (0, 0.057)
++++ graduation 0 4 466 13 21
++++ futility 0 406 1 279 289
++++ max_n 0 0 0 0 0
++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ post_p NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51) 0.43 (0.43, 0.43) NA (NA, NA)
++++ rate 0 (0, 0.07) 0.019 (0, 0.054) 0 (0, 0.143) 0.044 (0, 0.13) 0 (0, 0.128)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4
all count 1 330 4 5
all time_stop 10 (10, 10) 29 (13, 50) 12 (11, 17) 16 (12, 30)
all n_trt 59 (59, 59) 200 (84, 382) 66 (56, 83) 66 (59, 206)
all n_control 99 (99, 99) 258 (102, 514) 104 (100, 131) 129 (107, 275)
all post_p 0.86 (0.86, 0.86) 1 (0.93, 1) 0.9 (0.86, 0.96) 0.92 (0.89, 0.93)
all order 1 (1, 1) 1 (1, 3) 1 (1, 1) 1 (1, 1.6)
HRD+ count 66 6 11
HRD+ time_stop 52 (44, 58) 46 (42, 53) 47 (40, 55)
HRD+ n_trt 52 (50, 65) 54 (50, 58) 51 (51, 64)
HRD+ n_control 72 (52, 85) 59 (47, 70) 58 (45, 74)
HRD+ post_p 0.99 (0.92, 1) 0.92 (0.89, 0.98) 0.95 (0.87, 0.99)
HRD+ order 2 (1, 3) 2.5 (2, 4.5) 2 (1, 5)
TP53+ count 2 267 3 4
TP53+ time_stop 28 (23, 34) 39 (28, 54) 37 (31, 39) 26 (23, 50)
TP53+ n_trt 60 (53, 66) 88 (57, 145) 61 (59, 79) 70 (58, 180)
TP53+ n_control 88 (70, 105) 133 (83, 207) 127 (112, 130) 80 (61, 215)
TP53+ post_p 0.97 (0.95, 0.98) 0.99 (0.95, 1) 0.95 (0.94, 0.97) 0.92 (0.88, 0.96)
TP53+ order 1.5 (1.1, 1.9) 2 (1, 3) 2 (2, 2.8) 1 (1, 3.1)
TEfus+ count 183 1 3
TEfus+ time_stop 39 (26, 56) 39 (39, 39) 35 (33, 43)
TEfus+ n_trt 78 (54, 117) 134 (134, 134) 78 (56, 118)
TEfus+ n_control 116 (71, 184) 133 (133, 133) 99 (93, 118)
TEfus+ post_p 0.99 (0.95, 1) 0.9 (0.9, 0.9) 0.97 (0.94, 0.99)
TEfus+ order 2 (1, 4) 2 (2, 2) 2 (1.2, 2)
PI3K+ count 1 194 3
PI3K+ time_stop 28 (28, 28) 38 (25, 54) 26 (24, 27)
PI3K+ n_trt 54 (54, 54) 78 (54, 131) 54 (52, 67)
PI3K+ n_control 72 (72, 72) 120 (72, 182) 77 (62, 94)
PI3K+ post_p 0.93 (0.93, 0.93) 0.99 (0.95, 1) 0.93 (0.89, 0.98)
PI3K+ order 1 (1, 1) 2 (1, 4) 1 (1, 1.8)
Futility:
signature var TC1 TC2 TC3 TC4
all count 103 26 39
all time_stop 46 (34, 57) 54 (36, 59) 47 (27, 59)
all n_trt 164 (128, 231) 188 (148, 316) 154 (111, 249)
all n_control 474 (305, 623) 546 (324, 668) 458 (243, 607)
all post_p 0 (0, 0.03) 0.01 (0, 0.04) 0.01 (0, 0.06)
all order 3 (2, 6) 4 (2.5, 6) 3 (1, 6)
HRD+ count 28 37 31
HRD+ time_stop 54 (49, 58) 52 (41, 59) 55 (45, 59)
HRD+ n_trt 52 (50, 63) 53 (50, 66) 52 (50, 61)
HRD+ n_control 86 (63, 95) 77 (57, 99) 78 (56, 98)
HRD+ post_p 0.05 (0.02, 0.17) 0.08 (0.02, 0.24) 0.09 (0.03, 0.22)
HRD+ order 4 (2, 6.3) 4 (2, 7) 4 (2, 8)
TP53+ count 294 1 159 182
TP53+ time_stop 42 (29, 56) 27 (27, 27) 40 (28, 56) 39 (27, 56)
TP53+ n_trt 68 (51, 108) 71 (71, 71) 72 (51, 128) 66 (51, 118)
TP53+ n_control 148 (91, 222) 91 (91, 91) 143 (91, 222) 137 (82, 219)
TP53+ post_p 0.05 (0.01, 0.18) 0.05 (0.05, 0.05) 0.07 (0.01, 0.23) 0.09 (0.01, 0.23)
TP53+ order 2 (1, 5) 3 (3, 3) 2 (1, 5) 2 (1, 5)
TEfus+ count 191 1 129 107
TEfus+ time_stop 45 (33, 57) 32 (32, 32) 45 (31, 58) 45 (33, 57)
TEfus+ n_trt 65 (51, 106) 60 (60, 60) 68 (51, 117) 67 (50, 106)
TEfus+ n_control 141 (94, 193) 81 (81, 81) 144 (82, 199) 141 (92, 197)
TEfus+ post_p 0.03 (0, 0.15) 0.15 (0.15, 0.15) 0.05 (0.01, 0.17) 0.06 (0.01, 0.15)
TEfus+ order 3 (1, 5) 1 (1, 1) 3 (1, 6) 3 (1, 6)
PI3K+ count 240 125 164
PI3K+ time_stop 43 (30, 55) 45 (31, 56) 38 (26, 56)
PI3K+ n_trt 67 (51, 114) 73 (54, 134) 67 (52, 118)
PI3K+ n_control 141 (87, 211) 154 (90, 207) 120 (70, 207)
PI3K+ post_p 0.05 (0, 0.14) 0.05 (0.01, 0.16) 0.06 (0.01, 0.19)
PI3K+ order 3 (1, 6) 3 (1, 7) 2 (1, 6)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC1 time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
all TC1 n 37 (37, 37) 4 (4, 4) 0 (0, 0) 4 (4, 4) 3 (3, 3) 3 (3, 3) 2 (2, 2) 2 (2, 2) 0 (0, 0) 0 (0, 0) 3 (3, 3) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.51 (0.51, 0.51) 0.55 (0.55, 0.55) NA (NA, NA) 0.55 (0.55, 0.55) 0.55 (0.55, 0.55) 0.51 (0.51, 0.51) 0.52 (0.52, 0.52) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.005 (0.005, 0.005) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC2 count 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330
all TC2 time 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50) 29 (13, 50)
all TC2 n 71 (24, 161) 10 (3, 26) 4 (1, 8) 19 (7, 39) 26 (13, 52) 14 (6, 30) 15 (7, 29) 10 (4, 19) 10 (3, 25) 0 (0, 0) 7 (2, 18) 1 (0, 4) 0 (0, 1) 2 (0, 5) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.9 (0.59, 1) 0.62 (0.51, 0.93) 0.54 (0.5, 0.68) 0.67 (0.52, 0.96) 0.72 (0.53, 0.98) 0.66 (0.52, 0.95) 0.62 (0.52, 0.92) 0.59 (0.51, 0.85) 0.62 (0.52, 0.91) NA (NA, NA) 0.58 (0.51, 0.86) 0.53 (0.51, 0.6) 0.52 (0.51, 0.56) 0.54 (0.51, 0.64) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.008 (0, 0.012) 0.005 (0, 0.015) 0 (0, 0.016) 0.008 (0, 0.015) 0.008 (0, 0.014) 0.006 (0, 0.015) 0.008 (0, 0.014) 0.006 (0, 0.016) 0.004 (0, 0.014) NA (NA, NA) 0 (0, 0.015) 0 (0, 0.018) 0 (0, 0) 0 (0, 0.016) 0 (0, 0) 0 (0, 0.018)
all TC3 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC3 time 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17)
all TC3 n 17 (13, 27) 1 (0, 3) 2 (0, 3) 6 (4, 9) 6 (3, 11) 5 (3, 7) 4 (2, 5) 5 (3, 7) 8 (6, 15) 0 (0, 0) 8 (2, 9) 2 (1, 3) 0 (0, 1) 2 (1, 2) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.61 (0.53, 0.73) 0.57 (0.57, 0.57) 0.51 (0.51, 0.51) 0.55 (0.54, 0.56) 0.52 (0.51, 0.54) 0.53 (0.51, 0.55) 0.53 (0.51, 0.56) 0.53 (0.52, 0.57) 0.58 (0.52, 0.63) NA (NA, NA) 0.52 (0.52, 0.57) 0.53 (0.53, 0.53) 0.5 (0.5, 0.5) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.005 (0, 0.014) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.006) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.009) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC4 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC4 time 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30) 16 (12, 30)
all TC4 n 13 (9, 53) 7 (6, 18) 1 (0, 5) 11 (9, 13) 9 (5, 31) 13 (8, 30) 5 (2, 13) 6 (3, 19) 4 (2, 14) 0 (0, 0) 4 (2, 6) 1 (1, 4) 0 (0, 1) 2 (2, 3) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.54 (0.51, 0.68) 0.56 (0.52, 0.78) 0.54 (0.52, 0.61) 0.57 (0.56, 0.62) 0.55 (0.53, 0.58) 0.54 (0.52, 0.72) 0.54 (0.51, 0.58) 0.57 (0.53, 0.64) 0.55 (0.53, 0.56) NA (NA, NA) 0.56 (0.51, 0.65) 0.54 (0.52, 0.55) NA (NA, NA) 0.52 (0.52, 0.54) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.012 (0.005, 0.015) 0 (0, 0.011) 0 (0, 0.006) 0.011 (0, 0.014) 0 (0, 0.019) 0.009 (0, 0.012) 0 (0, 0.008) 0 (0, 0.011) 0 (0, 0.013) NA (NA, NA) 0 (0, 0.02) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 66 66 66 66 66 66 66 66
HRD+ TC2 time 52 (44, 58) 52 (44, 58) 52 (44, 58) 52 (44, 58) 52 (44, 58) 52 (44, 58) 52 (44, 58) 52 (44, 58)
HRD+ TC2 n 29 (18, 37) 0 (0, 0) 18 (11, 26) 3 (1, 6) 1 (0, 2) 4 (1, 7) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.93 (0.75, 0.99) NA (NA, NA) 0.88 (0.72, 0.96) 0.57 (0.51, 0.74) 0.53 (0.51, 0.56) 0.59 (0.51, 0.83) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.008 (0.004, 0.012) 0 (0, 0) 0.007 (0.002, 0.013) 0.007 (0, 0.027) 0 (0, 0.045) 0 (0, 0.019) 0 (0, 0) 0 (0, 0.029)
HRD+ TC3 count 6 6 6 6 6 6 6 6
HRD+ TC3 time 46 (42, 53) 46 (42, 53) 46 (42, 53) 46 (42, 53) 46 (42, 53) 46 (42, 53) 46 (42, 53) 46 (42, 53)
HRD+ TC3 n 26 (17, 33) 0 (0, 0) 20 (14, 25) 2 (2, 6) 0 (0, 2) 6 (2, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.81 (0.73, 0.89) NA (NA, NA) 0.78 (0.72, 0.88) 0.52 (0.51, 0.59) 0.52 (0.5, 0.53) 0.57 (0.52, 0.62) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.01 (0.004, 0.015) NA (NA, NA) 0.012 (0.008, 0.015) 0 (0, 0.026) 0.022 (0.004, 0.029) 0.007 (0.003, 0.019) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 11 11 11 11 11 11 11 11
HRD+ TC4 time 47 (40, 55) 47 (40, 55) 47 (40, 55) 47 (40, 55) 47 (40, 55) 47 (40, 55) 47 (40, 55) 47 (40, 55)
HRD+ TC4 n 24 (20, 33) 0 (0, 0) 16 (13, 22) 4 (3, 7) 0 (0, 1) 5 (1, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.74 (0.71, 0.87) NA (NA, NA) 0.78 (0.72, 0.98) 0.54 (0.51, 0.6) 0.54 (0.53, 0.54) 0.57 (0.51, 0.7) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.014 (0.006, 0.018) NA (NA, NA) 0.009 (0.006, 0.012) 0.011 (0, 0.016) 0 (0, 0) 0.009 (0, 0.025) NA (NA, NA) 0 (0, 0)
TP53+ TC1 count 2 2 2 2 2 2 2 2
TP53+ TC1 time 28 (23, 34) 28 (23, 34) 28 (23, 34) 28 (23, 34) 28 (23, 34) 28 (23, 34) 28 (23, 34) 28 (23, 34)
TP53+ TC1 n 24 (22, 26) 18 (16, 21) 10 (8, 12) 6 (5, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1)
TP53+ TC1 post_p 0.8 (0.79, 0.81) 0.8 (0.79, 0.81) 0.66 (0.61, 0.71) 0.59 (0.58, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.009 (0.006, 0.012) 0.006 (0.001, 0.01) 0.002 (0, 0.004) 0.007 (0.001, 0.012) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0)
TP53+ TC2 count 267 267 267 267 267 267 267 267
TP53+ TC2 time 39 (28, 54) 39 (28, 54) 39 (28, 54) 39 (28, 54) 39 (28, 54) 39 (28, 54) 39 (28, 54) 39 (28, 54)
TP53+ TC2 n 34 (20, 61) 20 (9, 35) 19 (10, 33) 12 (6, 23) 0 (0, 1) 2 (0, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.85 (0.72, 0.99) 0.8 (0.67, 0.98) 0.76 (0.62, 0.96) 0.73 (0.54, 0.91) 0.53 (0.5, 0.57) 0.55 (0.51, 0.67) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.009 (0.004, 0.013) 0.008 (0.002, 0.014) 0.009 (0.003, 0.014) 0.008 (0, 0.016) 0 (0, 0.026) 0 (0, 0.019) NA (NA, NA) 0 (0, 0.025)
TP53+ TC3 count 3 3 3 3 3 3 3 3
TP53+ TC3 time 37 (31, 39) 37 (31, 39) 37 (31, 39) 37 (31, 39) 37 (31, 39) 37 (31, 39) 37 (31, 39) 37 (31, 39)
TP53+ TC3 n 15 (13, 27) 22 (15, 26) 8 (6, 22) 9 (8, 10) 1 (1, 2) 5 (3, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.73 (0.71, 0.75) 0.81 (0.73, 0.85) 0.63 (0.54, 0.78) 0.52 (0.51, 0.6) 0.5 (0.5, 0.5) 0.57 (0.52, 0.69) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.013 (0.011, 0.015) 0.009 (0.008, 0.012) 0.01 (0.008, 0.016) 0.016 (0.003, 0.02) 0 (0, 0.023) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 4 4 4 4 4 4 4 4
TP53+ TC4 time 26 (23, 50) 26 (23, 50) 26 (23, 50) 26 (23, 50) 26 (23, 50) 26 (23, 50) 26 (23, 50) 26 (23, 50)
TP53+ TC4 n 26 (19, 66) 22 (15, 39) 10 (10, 36) 8 (7, 34) 0 (0, 2) 4 (3, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.78 (0.73, 0.82) 0.78 (0.71, 0.86) 0.6 (0.56, 0.7) 0.57 (0.54, 0.81) 0.5 (0.5, 0.5) 0.52 (0.52, 0.62) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.006 (0.005, 0.011) 0.009 (0.002, 0.015) 0.004 (0, 0.012) 0.007 (0, 0.016) 0 (0, 0) 0.014 (0.002, 0.033) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 183 183 183 183 183 183 183 183
TEfus+ TC2 time 39 (26, 56) 39 (26, 56) 39 (26, 56) 39 (26, 56) 39 (26, 56) 39 (26, 56) 39 (26, 56) 39 (26, 56)
TEfus+ TC2 n 5 (2, 9) 26 (16, 44) 20 (10, 31) 13 (6, 22) 10 (5, 20) 2 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.57 (0.51, 0.74) 0.85 (0.72, 0.98) 0.78 (0.7, 0.96) 0.74 (0.56, 0.92) 0.72 (0.54, 0.92) 0.55 (0.51, 0.64) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.008 (0, 0.018) 0.008 (0.003, 0.014) 0.009 (0.003, 0.014) 0.009 (0.001, 0.016) 0.007 (0, 0.016) 0 (0, 0.017) NA (NA, NA) 0.018 (0, 0.133)
TEfus+ TC3 count 1 1 1 1 1 1 1 1
TEfus+ TC3 time 39 (39, 39) 39 (39, 39) 39 (39, 39) 39 (39, 39) 39 (39, 39) 39 (39, 39) 39 (39, 39) 39 (39, 39)
TEfus+ TC3 n 4 (4, 4) 45 (45, 45) 28 (28, 28) 22 (22, 22) 29 (29, 29) 6 (6, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.51 (0.51, 0.51) 0.73 (0.73, 0.73) 0.72 (0.72, 0.72) 0.76 (0.76, 0.76) 0.76 (0.76, 0.76) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.015 (0.015, 0.015) 0.01 (0.01, 0.01) 0.015 (0.015, 0.015) 0.011 (0.011, 0.011) 0.014 (0.014, 0.014) 0.014 (0.014, 0.014) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 3 3 3 3 3 3 3 3
TEfus+ TC4 time 35 (33, 43) 35 (33, 43) 35 (33, 43) 35 (33, 43) 35 (33, 43) 35 (33, 43) 35 (33, 43) 35 (33, 43)
TEfus+ TC4 n 4 (3, 7) 26 (19, 40) 20 (12, 28) 17 (11, 17) 10 (8, 20) 5 (2, 7) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.61 (0.52, 0.67) 0.73 (0.71, 0.79) 0.77 (0.66, 0.94) 0.7 (0.65, 0.71) 0.85 (0.67, 0.88) 0.57 (0.53, 0.61) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.008 (0.002, 0.012) 0.01 (0.008, 0.016) 0.012 (0.002, 0.013) 0.017 (0.013, 0.018) 0.009 (0.007, 0.009) 0 (0, 0.016) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 1 1 1 1 1 1 1 1
PI3K+ TC1 time 28 (28, 28) 28 (28, 28) 28 (28, 28) 28 (28, 28) 28 (28, 28) 28 (28, 28) 28 (28, 28) 28 (28, 28)
PI3K+ TC1 n 9 (9, 9) 21 (21, 21) 15 (15, 15) 6 (6, 6) 0 (0, 0) 2 (2, 2) 1 (1, 1) 0 (0, 0)
PI3K+ TC1 post_p 0.61 (0.61, 0.61) 0.72 (0.72, 0.72) 0.72 (0.72, 0.72) 0.5 (0.5, 0.5) NA (NA, NA) 0.55 (0.55, 0.55) 0.54 (0.54, 0.54) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.009 (0.009, 0.009) 0.009 (0.009, 0.009) 0 (0, 0) 0.016 (0.016, 0.016) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA)
PI3K+ TC2 count 194 194 194 194 194 194 194 194
PI3K+ TC2 time 38 (25, 54) 38 (25, 54) 38 (25, 54) 38 (25, 54) 38 (25, 54) 38 (25, 54) 38 (25, 54) 38 (25, 54)
PI3K+ TC2 n 16 (7, 30) 26 (16, 49) 21 (11, 35) 13 (7, 23) 0 (0, 0) 2 (0, 5) 2 (0, 5) 0 (0, 0)
PI3K+ TC2 post_p 0.78 (0.57, 0.96) 0.84 (0.72, 0.98) 0.81 (0.71, 0.98) 0.74 (0.53, 0.91) NA (NA, NA) 0.54 (0.51, 0.62) 0.55 (0.51, 0.65) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.008 (0, 0.014) 0.008 (0.003, 0.014) 0.008 (0, 0.013) 0.009 (0, 0.016) NA (NA, NA) 0 (0, 0.019) 0 (0, 0.019) 0.018 (0.004, 0.033)
PI3K+ TC3 count 3 3 3 3 3 3 3 3
PI3K+ TC3 time 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27)
PI3K+ TC3 n 10 (9, 13) 23 (15, 23) 15 (11, 17) 10 (8, 14) 0 (0, 0) 1 (0, 2) 0 (0, 3) 0 (0, 0)
PI3K+ TC3 post_p 0.7 (0.6, 0.75) 0.8 (0.73, 0.81) 0.76 (0.74, 0.77) 0.58 (0.54, 0.68) NA (NA, NA) 0.53 (0.52, 0.53) 0.52 (0.52, 0.52) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.007 (0.001, 0.01) 0.005 (0.005, 0.006) 0 (0, 0.005) 0.008 (0.002, 0.011) NA (NA, NA) 0 (0, 0) 0.03 (0.03, 0.03) NA (NA, NA)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 103 103 103 103 103 103 103 103 103 103 103 103 103 103 103 103
all TC1 time 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57)
all TC1 n 35 (23, 61) 13 (7, 27) 5 (2, 8) 17 (9, 41) 17 (9, 47) 15 (9, 34) 13 (7, 23) 10 (5, 21) 12 (6, 21) 0 (0, 0) 8 (4, 20) 2 (0, 5) 0 (0, 1) 3 (0, 6) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.11 (0.01, 0.31) 0.24 (0.07, 0.45) 0.41 (0.22, 0.49) 0.18 (0.05, 0.45) 0.18 (0.04, 0.42) 0.21 (0.07, 0.45) 0.24 (0.05, 0.42) 0.31 (0.07, 0.46) 0.25 (0.07, 0.45) NA (NA, NA) 0.31 (0.09, 0.46) 0.45 (0.34, 0.49) 0.47 (0.43, 0.5) 0.42 (0.31, 0.49) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.027 (0.02, 0.035) 0.027 (0.019, 0.04) 0.027 (0.017, 0.067) 0.026 (0.018, 0.04) 0.026 (0.017, 0.043) 0.027 (0.019, 0.038) 0.026 (0.018, 0.042) 0.027 (0.018, 0.045) 0.029 (0.02, 0.051) 0 (0, 0) 0.029 (0.017, 0.051) 0.037 (0.01, 0.078) 0.017 (0, 0.145) 0.031 (0.012, 0.109) NA (NA, NA) NA (NA, NA)
all TC3 count 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26
all TC3 time 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59) 54 (36, 59)
all TC3 n 42 (22, 138) 12 (8, 28) 6 (2, 8) 20 (8, 42) 20 (13, 54) 13 (7, 30) 11 (8, 30) 11 (6, 22) 16 (10, 26) 0 (0, 0) 12 (8, 22) 2 (1, 6) 0 (0, 2) 4 (2, 7) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.19 (0.05, 0.44) 0.3 (0.12, 0.46) 0.33 (0.15, 0.47) 0.27 (0.09, 0.46) 0.32 (0.07, 0.45) 0.31 (0.12, 0.45) 0.32 (0.14, 0.48) 0.26 (0.05, 0.44) 0.26 (0.07, 0.43) NA (NA, NA) 0.3 (0.12, 0.48) 0.42 (0.22, 0.48) 0.44 (0.38, 0.48) 0.4 (0.32, 0.47) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.023 (0.018, 0.029) 0.023 (0.017, 0.03) 0.029 (0.022, 0.101) 0.023 (0.016, 0.04) 0.022 (0.017, 0.038) 0.025 (0.019, 0.033) 0.023 (0.016, 0.033) 0.025 (0.019, 0.041) 0.025 (0.02, 0.034) NA (NA, NA) 0.024 (0.018, 0.036) 0.038 (0.017, 0.083) 0.062 (0.013, 0.141) 0.022 (0.014, 0.048) NA (NA, NA) 0 (0, 0)
all TC4 count 39 39 39 39 39 39 39 39 39 39 39 39 39 39 39 39
all TC4 time 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59) 47 (27, 59)
all TC4 n 37 (21, 100) 14 (7, 24) 4 (1, 7) 14 (8, 21) 16 (9, 40) 11 (7, 26) 11 (5, 20) 9 (5, 15) 10 (4, 23) 0 (0, 0) 7 (3, 22) 2 (0, 6) 0 (0, 1) 3 (1, 6) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.19 (0.04, 0.42) 0.34 (0.12, 0.48) 0.42 (0.3, 0.48) 0.26 (0.13, 0.42) 0.31 (0.14, 0.48) 0.27 (0.07, 0.46) 0.32 (0.08, 0.45) 0.34 (0.17, 0.43) 0.35 (0.11, 0.49) NA (NA, NA) 0.41 (0.16, 0.48) 0.43 (0.37, 0.49) 0.48 (0.48, 0.48) 0.41 (0.29, 0.49) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.022 (0.017, 0.031) 0.024 (0.016, 0.036) 0.03 (0.017, 0.079) 0.025 (0.018, 0.038) 0.022 (0.018, 0.033) 0.025 (0.019, 0.049) 0.024 (0.017, 0.054) 0.024 (0.016, 0.039) 0.025 (0.015, 0.052) NA (NA, NA) 0.024 (0.016, 0.053) 0.028 (0.009, 0.064) 0.094 (0, 0.201) 0.029 (0.012, 0.073) NA (NA, NA) 0 (0, 0)
HRD+ TC1 count 28 28 28 28 28 28 28 28
HRD+ TC1 time 54 (49, 58) 54 (49, 58) 54 (49, 58) 54 (49, 58) 54 (49, 58) 54 (49, 58) 54 (49, 58) 54 (49, 58)
HRD+ TC1 n 25 (12, 37) 0 (0, 0) 20 (9, 32) 3 (2, 7) 0 (0, 2) 4 (0, 7) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.28 (0.12, 0.46) NA (NA, NA) 0.25 (0.06, 0.48) 0.45 (0.32, 0.49) 0.46 (0.44, 0.47) 0.39 (0.24, 0.48) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.024 (0.018, 0.032) NA (NA, NA) 0.024 (0.018, 0.04) 0.029 (0.017, 0.06) 0.04 (0.025, 0.066) 0.027 (0.018, 0.045) NA (NA, NA) 0.021 (0.021, 0.021)
HRD+ TC3 count 37 37 37 37 37 37 37 37
HRD+ TC3 time 52 (41, 59) 52 (41, 59) 52 (41, 59) 52 (41, 59) 52 (41, 59) 52 (41, 59) 52 (41, 59) 52 (41, 59)
HRD+ TC3 n 25 (15, 38) 0 (0, 0) 18 (9, 32) 4 (2, 7) 0 (0, 2) 4 (2, 9) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.28 (0.09, 0.48) NA (NA, NA) 0.38 (0.08, 0.47) 0.44 (0.34, 0.49) 0.46 (0.45, 0.48) 0.38 (0.22, 0.47) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.022 (0.017, 0.033) 0 (0, 0) 0.023 (0.018, 0.033) 0.03 (0.013, 0.076) 0.041 (0, 0.131) 0.031 (0.016, 0.067) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 31 31 31 31 31 31 31 31
HRD+ TC4 time 55 (45, 59) 55 (45, 59) 55 (45, 59) 55 (45, 59) 55 (45, 59) 55 (45, 59) 55 (45, 59) 55 (45, 59)
HRD+ TC4 n 25 (15, 39) 0 (0, 0) 18 (7, 28) 4 (1, 7) 0 (0, 2) 3 (1, 7) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.32 (0.12, 0.46) NA (NA, NA) 0.28 (0.17, 0.45) 0.43 (0.34, 0.48) 0.47 (0.46, 0.49) 0.39 (0.27, 0.47) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.022 (0.018, 0.028) NA (NA, NA) 0.023 (0.016, 0.032) 0.032 (0.018, 0.094) 0.034 (0.002, 0.087) 0.031 (0.016, 0.098) 0 (0, 0) 0 (0, 0)
TP53+ TC1 count 294 294 294 294 294 294 294 294
TP53+ TC1 time 42 (29, 56) 42 (29, 56) 42 (29, 56) 42 (29, 56) 42 (29, 56) 42 (29, 56) 42 (29, 56) 42 (29, 56)
TP53+ TC1 n 20 (10, 45) 15 (9, 34) 14 (7, 29) 11 (6, 25) 0 (0, 2) 3 (1, 7) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.23 (0.04, 0.47) 0.3 (0.08, 0.47) 0.32 (0.07, 0.47) 0.35 (0.12, 0.47) 0.47 (0.43, 0.5) 0.44 (0.3, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.024 (0.017, 0.039) 0.024 (0.016, 0.04) 0.023 (0.016, 0.044) 0.024 (0.016, 0.044) 0 (0, 0.133) 0.029 (0, 0.091) 0.046 (0.046, 0.046) 0.021 (0, 0.048)
TP53+ TC2 count 1 1 1 1 1 1 1 1
TP53+ TC2 time 27 (27, 27) 27 (27, 27) 27 (27, 27) 27 (27, 27) 27 (27, 27) 27 (27, 27) 27 (27, 27) 27 (27, 27)
TP53+ TC2 n 25 (25, 25) 25 (25, 25) 10 (10, 10) 8 (8, 8) 2 (2, 2) 1 (1, 1) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.27 (0.27, 0.27) 0.5 (0.5, 0.5) 0.3 (0.3, 0.3) 0.46 (0.46, 0.46) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.022 (0.022, 0.022) 0.009 (0.009, 0.009) 0.026 (0.026, 0.026) 0.031 (0.031, 0.031) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 159 159 159 159 159 159 159 159
TP53+ TC3 time 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56)
TP53+ TC3 n 22 (13, 48) 16 (8, 39) 14 (8, 32) 12 (6, 23) 0 (0, 2) 4 (2, 8) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.32 (0.06, 0.47) 0.33 (0.12, 0.48) 0.34 (0.16, 0.48) 0.37 (0.13, 0.48) 0.45 (0.41, 0.49) 0.44 (0.31, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.021 (0.016, 0.033) 0.022 (0.016, 0.036) 0.022 (0.015, 0.037) 0.023 (0.016, 0.043) 0.029 (0, 0.178) 0.028 (0.014, 0.064) NA (NA, NA) 0.05 (0.01, 0.091)
TP53+ TC4 count 182 182 182 182 182 182 182 182
TP53+ TC4 time 39 (27, 56) 39 (27, 56) 39 (27, 56) 39 (27, 56) 39 (27, 56) 39 (27, 56) 39 (27, 56) 39 (27, 56)
TP53+ TC4 n 21 (11, 52) 16 (10, 31) 13 (7, 30) 12 (7, 22) 0 (0, 1) 3 (1, 7) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.35 (0.09, 0.48) 0.32 (0.1, 0.48) 0.38 (0.12, 0.48) 0.36 (0.13, 0.47) 0.47 (0.43, 0.49) 0.44 (0.32, 0.5) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.021 (0.016, 0.04) 0.023 (0.016, 0.034) 0.022 (0.015, 0.039) 0.023 (0.015, 0.043) 0 (0, 0.105) 0.027 (0, 0.068) 0 (0, 0) 0 (0, 0.072)
TEfus+ TC1 count 191 191 191 191 191 191 191 191
TEfus+ TC1 time 45 (33, 57) 45 (33, 57) 45 (33, 57) 45 (33, 57) 45 (33, 57) 45 (33, 57) 45 (33, 57) 45 (33, 57)
TEfus+ TC1 n 5 (2, 10) 18 (9, 44) 14 (8, 30) 12 (6, 29) 9 (5, 18) 3 (0, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.41 (0.24, 0.49) 0.27 (0.06, 0.44) 0.26 (0.08, 0.46) 0.3 (0.08, 0.48) 0.31 (0.1, 0.47) 0.44 (0.33, 0.49) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.029 (0.017, 0.061) 0.024 (0.018, 0.036) 0.025 (0.017, 0.042) 0.025 (0.017, 0.042) 0.029 (0.017, 0.048) 0.035 (0.011, 0.085) NA (NA, NA) 0.03 (0.006, 0.064)
TEfus+ TC2 count 1 1 1 1 1 1 1 1
TEfus+ TC2 time 32 (32, 32) 32 (32, 32) 32 (32, 32) 32 (32, 32) 32 (32, 32) 32 (32, 32) 32 (32, 32) 32 (32, 32)
TEfus+ TC2 n 4 (4, 4) 13 (13, 13) 26 (26, 26) 11 (11, 11) 4 (4, 4) 2 (2, 2) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.46 (0.46, 0.46) 0.2 (0.2, 0.2) 0.49 (0.49, 0.49) 0.45 (0.45, 0.45) 0.4 (0.4, 0.4) 0.45 (0.45, 0.45) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.008 (0.008, 0.008) 0.025 (0.025, 0.025) 0.014 (0.014, 0.014) 0.011 (0.011, 0.011) 0.047 (0.047, 0.047) 0.037 (0.037, 0.037) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 129 129 129 129 129 129 129 129
TEfus+ TC3 time 45 (31, 58) 45 (31, 58) 45 (31, 58) 45 (31, 58) 45 (31, 58) 45 (31, 58) 45 (31, 58) 45 (31, 58)
TEfus+ TC3 n 5 (3, 10) 20 (9, 45) 14 (8, 31) 12 (6, 29) 11 (6, 19) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.42 (0.29, 0.49) 0.3 (0.07, 0.46) 0.33 (0.1, 0.46) 0.34 (0.12, 0.48) 0.34 (0.14, 0.48) 0.44 (0.32, 0.49) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.028 (0.014, 0.055) 0.021 (0.015, 0.038) 0.024 (0.015, 0.038) 0.023 (0.014, 0.039) 0.024 (0.015, 0.038) 0.028 (0.01, 0.078) NA (NA, NA) 0 (0, 0)
TEfus+ TC4 count 107 107 107 107 107 107 107 107
TEfus+ TC4 time 45 (33, 57) 45 (33, 57) 45 (33, 57) 45 (33, 57) 45 (33, 57) 45 (33, 57) 45 (33, 57) 45 (33, 57)
TEfus+ TC4 n 5 (2, 9) 19 (12, 47) 14 (7, 27) 12 (6, 26) 10 (5, 21) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.4 (0.27, 0.49) 0.28 (0.08, 0.48) 0.34 (0.08, 0.47) 0.33 (0.09, 0.48) 0.33 (0.1, 0.47) 0.45 (0.35, 0.5) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.029 (0.015, 0.092) 0.022 (0.016, 0.033) 0.024 (0.018, 0.044) 0.023 (0.015, 0.037) 0.027 (0.017, 0.05) 0.027 (0.01, 0.098) 0.035 (0.007, 0.064) 0 (0, 0)
PI3K+ TC1 count 240 240 240 240 240 240 240 240
PI3K+ TC1 time 43 (30, 55) 43 (30, 55) 43 (30, 55) 43 (30, 55) 43 (30, 55) 43 (30, 55) 43 (30, 55) 43 (30, 55)
PI3K+ TC1 n 14 (8, 28) 19 (10, 41) 15 (8, 33) 11 (6, 27) 0 (0, 0) 3 (0, 5) 3 (1, 7) 0 (0, 0)
PI3K+ TC1 post_p 0.33 (0.09, 0.48) 0.25 (0.06, 0.45) 0.28 (0.07, 0.46) 0.31 (0.1, 0.48) NA (NA, NA) 0.45 (0.35, 0.49) 0.45 (0.3, 0.49) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.024 (0.016, 0.039) 0.025 (0.017, 0.04) 0.025 (0.017, 0.038) 0.025 (0.017, 0.045) 0 (0, 0) 0.034 (0, 0.083) 0.029 (0.01, 0.094) 0.037 (0.007, 0.058)
PI3K+ TC3 count 125 125 125 125 125 125 125 125
PI3K+ TC3 time 45 (31, 56) 45 (31, 56) 45 (31, 56) 45 (31, 56) 45 (31, 56) 45 (31, 56) 45 (31, 56) 45 (31, 56)
PI3K+ TC3 n 16 (8, 31) 20 (9, 47) 15 (8, 35) 12 (6, 23) 0 (0, 0) 3 (1, 6) 4 (2, 7) 0 (0, 0)
PI3K+ TC3 post_p 0.36 (0.11, 0.48) 0.32 (0.05, 0.46) 0.31 (0.09, 0.48) 0.34 (0.08, 0.47) NA (NA, NA) 0.45 (0.36, 0.49) 0.42 (0.26, 0.49) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.022 (0.016, 0.039) 0.022 (0.016, 0.036) 0.022 (0.017, 0.037) 0.024 (0.017, 0.043) 0 (0, 0) 0.028 (0.009, 0.081) 0.027 (0.012, 0.069) NA (NA, NA)
PI3K+ TC4 count 164 164 164 164 164 164 164 164
PI3K+ TC4 time 38 (26, 56) 38 (26, 56) 38 (26, 56) 38 (26, 56) 38 (26, 56) 38 (26, 56) 38 (26, 56) 38 (26, 56)
PI3K+ TC4 n 14 (8, 30) 18 (10, 43) 15 (9, 32) 12 (6, 20) 0 (0, 0) 3 (1, 6) 3 (1, 6) 0 (0, 0)
PI3K+ TC4 post_p 0.33 (0.1, 0.47) 0.29 (0.06, 0.47) 0.28 (0.06, 0.46) 0.38 (0.11, 0.48) NA (NA, NA) 0.46 (0.37, 0.49) 0.44 (0.35, 0.49) NA (NA, NA)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.023 (0.015, 0.041) 0.022 (0.016, 0.033) 0.024 (0.015, 0.036) 0.023 (0.014, 0.041) NA (NA, NA) 0.026 (0, 0.071) 0.029 (0, 0.089) 0 (0, 0)