TC2 more effective in all the biomarker signatures
| signature | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| all | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| all | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| HRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| HRD+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| HRD+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| TP53+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| TP53+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| TEfus+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| TEfus+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| PI3K+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| PI3K+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| PI3K+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| —- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| —- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| —+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| —+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| —+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| –+- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| –+- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| –++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| –++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| –++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+– | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+– | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+– | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+-+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+-+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+-+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| -++- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -++- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -++- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| +— | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +— | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +— | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| +–+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +–+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +–+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +-+- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +-+- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +-++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +-++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++– | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++– | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| ++– | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++-+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++-+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| ++-+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| +++- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +++- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +++- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| ++++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | af = 1, hr = 1 |
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| Characteristics | Overall | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| Error signature | 0.334 | 0.008 | 0.272 | 0.034 | 0.044 |
| Error subgroup | 0.086 | 0.008 | 0.000 | 0.034 | 0.044 |
| Power signature | 0.660 | 0.000 | 0.660 | 0.000 | 0.000 |
| Power subgroup | 0.932 | 0.000 | 0.932 | 0.000 | 0.000 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 1 | 330 | 4 | 5 |
| all | futility | 0 | 103 | 0 | 26 | 39 |
| all | max_n | 0 | 0 | 0 | 0 | 0 |
| all | n | 658 (606, 706) | 209 (151, 304) | 301 (94, 503) | 298 (194, 443) | 290 (176, 438) |
| all | n_unique | 658 (606, 706) | 209 (151, 304) | 301 (94, 503) | 298 (194, 443) | 290 (176, 438) |
| all | time_trial | 60 (60, 60) | 60 (46, 60) | 42 (14, 60) | 60 (60, 60) | 60 (60, 60) |
| all | time_stop | NA (NA, NA) | 46 (34, 57) | 29 (13, 50) | 50 (18, 59) | 38 (17, 58) |
| all | post_p | NA (NA, NA) | 0 (0, 0.03) | 1 (1, 1) | 0.05 (0, 0.35) | 0.05 (0, 0.35) |
| all | rate | 0.018 (0.016, 0.019) | 0.025 (0.023, 0.029) | 0.011 (0.009, 0.012) | 0.021 (0.019, 0.024) | 0.021 (0.019, 0.024) |
| HRD+ | graduation | 0 | 0 | 66 | 6 | 11 |
| HRD+ | futility | 0 | 28 | 0 | 37 | 31 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 89 (74, 103) | 38 (23, 57) | 34 (8, 58) | 47 (30, 66) | 48 (26, 71) |
| HRD+ | n_unique | 89 (74, 103) | 38 (23, 57) | 34 (8, 58) | 47 (30, 66) | 48 (26, 71) |
| HRD+ | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (56, 60) | 60 (60, 60) | 60 (60, 60) |
| HRD+ | time_stop | NA (NA, NA) | 54 (49, 58) | 52 (44, 58) | 51 (42, 59) | 52 (43, 58) |
| HRD+ | post_p | NA (NA, NA) | 0.11 (0.01, 0.51) | 0.94 (0.63, 1) | 0.19 (0.03, 0.64) | 0.28 (0.04, 0.72) |
| HRD+ | rate | 0.018 (0.014, 0.022) | 0.025 (0.019, 0.034) | 0.01 (0.006, 0.016) | 0.023 (0.017, 0.03) | 0.021 (0.016, 0.028) |
| TP53+ | graduation | 0 | 2 | 267 | 3 | 4 |
| TP53+ | futility | 0 | 294 | 1 | 159 | 182 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TP53+ | n | 240 (211, 267) | 78 (50, 135) | 91 (40, 172) | 116 (55, 183) | 106 (52, 184) |
| TP53+ | n_unique | 240 (211, 267) | 78 (50, 135) | 91 (40, 172) | 116 (55, 183) | 106 (52, 184) |
| TP53+ | time_trial | 60 (60, 60) | 53 (32, 60) | 56 (30, 60) | 60 (35, 60) | 60 (32, 60) |
| TP53+ | time_stop | NA (NA, NA) | 42 (28, 56) | 39 (27, 54) | 40 (28, 56) | 39 (27, 56) |
| TP53+ | post_p | NA (NA, NA) | 0.03 (0, 0.23) | 1 (0.95, 1) | 0.15 (0.01, 0.58) | 0.15 (0.01, 0.59) |
| TP53+ | rate | 0.018 (0.015, 0.02) | 0.026 (0.021, 0.031) | 0.011 (0.009, 0.013) | 0.021 (0.017, 0.026) | 0.021 (0.018, 0.027) |
| TEfus+ | graduation | 0 | 0 | 183 | 1 | 3 |
| TEfus+ | futility | 0 | 191 | 1 | 129 | 107 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 204 (178, 232) | 78 (50, 124) | 75 (30, 147) | 103 (57, 156) | 98 (53, 152) |
| TEfus+ | n_unique | 204 (178, 232) | 78 (50, 124) | 75 (30, 147) | 103 (57, 156) | 98 (53, 152) |
| TEfus+ | time_trial | 60 (60, 60) | 60 (39, 60) | 60 (33, 60) | 60 (40, 60) | 60 (44, 60) |
| TEfus+ | time_stop | NA (NA, NA) | 45 (33, 57) | 39 (26, 56) | 44 (31, 58) | 45 (33, 57) |
| TEfus+ | post_p | NA (NA, NA) | 0.04 (0, 0.26) | 1 (0.92, 1) | 0.15 (0.02, 0.55) | 0.16 (0.01, 0.58) |
| TEfus+ | rate | 0.017 (0.015, 0.02) | 0.025 (0.02, 0.031) | 0.011 (0.008, 0.013) | 0.021 (0.018, 0.026) | 0.021 (0.018, 0.027) |
| PI3K+ | graduation | 0 | 1 | 194 | 3 | 0 |
| PI3K+ | futility | 0 | 240 | 0 | 125 | 164 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 |
| PI3K+ | n | 223 (194, 249) | 82 (51, 134) | 78 (29, 155) | 114 (60, 176) | 102 (54, 164) |
| PI3K+ | n_unique | 223 (194, 249) | 82 (51, 134) | 78 (29, 155) | 114 (60, 176) | 102 (54, 164) |
| PI3K+ | time_trial | 60 (60, 60) | 60 (34, 60) | 60 (30, 60) | 60 (41, 60) | 60 (33, 60) |
| PI3K+ | time_stop | NA (NA, NA) | 43 (29, 55) | 38 (25, 54) | 44 (31, 56) | 38 (26, 56) |
| PI3K+ | post_p | NA (NA, NA) | 0.03 (0, 0.25) | 1 (0.91, 1) | 0.18 (0.01, 0.6) | 0.15 (0.01, 0.55) |
| PI3K+ | rate | 0.017 (0.015, 0.02) | 0.025 (0.021, 0.031) | 0.01 (0.008, 0.013) | 0.021 (0.017, 0.026) | 0.022 (0.019, 0.027) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 1 | 330 | 4 | 5 |
| —- | futility | 0 | 103 | 0 | 26 | 39 |
| —- | max_n | 0 | 0 | 0 | 0 | 0 |
| —- | n | 212 (180, 240) | 37 (23, 87) | 112 (28, 211) | 62 (24, 173) | 64 (25, 174) |
| —- | n_unique | 212 (180, 240) | 37 (23, 87) | 112 (28, 211) | 62 (24, 173) | 64 (25, 174) |
| —- | post_p | NA (NA, NA) | 0.06 (0, 0.31) | 1 (0.92, 1) | 0.18 (0.02, 0.63) | 0.19 (0.03, 0.62) |
| —- | rate | 0.018 (0.015, 0.02) | 0.027 (0.022, 0.035) | 0.01 (0.008, 0.013) | 0.022 (0.017, 0.03) | 0.021 (0.017, 0.029) |
| —+ | graduation | 0 | 2 | 384 | 7 | 5 |
| —+ | futility | 0 | 254 | 0 | 130 | 174 |
| —+ | max_n | 0 | 0 | 0 | 0 | 0 |
| —+ | n | 46 (36, 56) | 15 (8, 35) | 15 (4, 40) | 23 (9, 45) | 18 (8, 41) |
| —+ | n_unique | 46 (36, 56) | 15 (8, 35) | 15 (4, 40) | 23 (9, 45) | 18 (8, 41) |
| —+ | post_p | NA (NA, NA) | 0.2 (0.04, 0.57) | 0.86 (0.46, 0.98) | 0.36 (0.07, 0.76) | 0.31 (0.07, 0.66) |
| —+ | rate | 0.017 (0.012, 0.023) | 0.026 (0.018, 0.042) | 0.01 (0.005, 0.019) | 0.021 (0.014, 0.034) | 0.022 (0.015, 0.037) |
| –+- | graduation | 0 | 1 | 379 | 5 | 8 |
| –+- | futility | 0 | 215 | 1 | 131 | 119 |
| –+- | max_n | 0 | 0 | 0 | 0 | 0 |
| –+- | n | 13 (8, 18) | 6 (3, 12) | 5 (2, 11) | 7 (3, 13) | 7 (3, 13) |
| –+- | n_unique | 13 (8, 18) | 6 (3, 12) | 5 (2, 11) | 7 (3, 13) | 7 (3, 13) |
| –+- | post_p | NA (NA, NA) | 0.39 (0.14, 0.65) | 0.66 (0.39, 0.88) | 0.42 (0.18, 0.72) | 0.46 (0.2, 0.73) |
| –+- | rate | 0.018 (0.009, 0.032) | 0.026 (0.012, 0.056) | 0.01 (0, 0.027) | 0.022 (0.009, 0.046) | 0.022 (0.009, 0.049) |
| –++ | graduation | 0 | 2 | 422 | 6 | 8 |
| –++ | futility | 0 | 313 | 1 | 198 | 217 |
| –++ | max_n | 0 | 0 | 0 | 0 | 0 |
| –++ | n | 68 (55, 82) | 20 (10, 49) | 24 (9, 56) | 30 (11, 62) | 24 (12, 60) |
| –++ | n_unique | 68 (55, 82) | 20 (10, 49) | 24 (9, 56) | 30 (11, 62) | 24 (12, 60) |
| –++ | post_p | NA (NA, NA) | 0.17 (0.02, 0.52) | 0.92 (0.64, 1) | 0.3 (0.06, 0.73) | 0.27 (0.04, 0.7) |
| –++ | rate | 0.017 (0.013, 0.022) | 0.026 (0.018, 0.039) | 0.011 (0.007, 0.016) | 0.021 (0.015, 0.034) | 0.023 (0.016, 0.033) |
| -+– | graduation | 0 | 3 | 413 | 7 | 9 |
| -+– | futility | 0 | 313 | 1 | 162 | 195 |
| -+– | max_n | 0 | 0 | 0 | 0 | 0 |
| -+– | n | 87 (70, 101) | 20 (10, 49) | 33 (14, 76) | 33 (13, 75) | 33 (12, 77) |
| -+– | n_unique | 87 (70, 101) | 20 (10, 49) | 33 (14, 76) | 33 (13, 75) | 33 (12, 77) |
| -+– | post_p | NA (NA, NA) | 0.14 (0.01, 0.47) | 0.96 (0.73, 1) | 0.29 (0.06, 0.7) | 0.29 (0.04, 0.75) |
| -+– | rate | 0.018 (0.014, 0.022) | 0.027 (0.02, 0.04) | 0.011 (0.007, 0.016) | 0.022 (0.016, 0.032) | 0.021 (0.015, 0.032) |
| -+-+ | graduation | 0 | 4 | 430 | 8 | 9 |
| -+-+ | futility | 0 | 362 | 1 | 217 | 248 |
| -+-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+-+ | n | 56 (42, 69) | 16 (9, 40) | 19 (7, 43) | 25 (9, 52) | 21 (10, 51) |
| -+-+ | n_unique | 56 (42, 69) | 16 (9, 40) | 19 (7, 43) | 25 (9, 52) | 21 (10, 51) |
| -+-+ | post_p | NA (NA, NA) | 0.19 (0.04, 0.56) | 0.9 (0.58, 0.99) | 0.33 (0.08, 0.72) | 0.29 (0.07, 0.7) |
| -+-+ | rate | 0.017 (0.013, 0.023) | 0.026 (0.017, 0.04) | 0.011 (0.006, 0.017) | 0.022 (0.015, 0.034) | 0.023 (0.016, 0.034) |
| -++- | graduation | 0 | 3 | 440 | 8 | 10 |
| -++- | futility | 0 | 370 | 1 | 230 | 241 |
| -++- | max_n | 0 | 0 | 0 | 0 | 0 |
| -++- | n | 49 (37, 63) | 14 (8, 35) | 18 (8, 40) | 22 (8, 46) | 20 (8, 45) |
| -++- | n_unique | 49 (37, 63) | 14 (8, 35) | 18 (8, 40) | 22 (8, 46) | 20 (8, 45) |
| -++- | post_p | NA (NA, NA) | 0.21 (0.05, 0.56) | 0.89 (0.6, 0.98) | 0.32 (0.07, 0.71) | 0.32 (0.07, 0.71) |
| -++- | rate | 0.017 (0.012, 0.023) | 0.026 (0.018, 0.04) | 0.011 (0.006, 0.017) | 0.022 (0.015, 0.034) | 0.022 (0.014, 0.036) |
| -+++ | graduation | 0 | 4 | 452 | 8 | 10 |
| -+++ | futility | 0 | 399 | 1 | 266 | 283 |
| -+++ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+++ | n | 37 (27, 48) | 12 (6, 32) | 12 (5, 24) | 17 (7, 37) | 15 (7, 37) |
| -+++ | n_unique | 37 (27, 48) | 12 (6, 32) | 12 (5, 24) | 17 (7, 37) | 15 (7, 37) |
| -+++ | post_p | NA (NA, NA) | 0.24 (0.05, 0.6) | 0.83 (0.47, 0.97) | 0.37 (0.09, 0.71) | 0.34 (0.09, 0.75) |
| -+++ | rate | 0.017 (0.012, 0.024) | 0.026 (0.016, 0.044) | 0.011 (0.005, 0.019) | 0.021 (0.014, 0.036) | 0.022 (0.015, 0.037) |
| +— | graduation | 0 | 1 | 372 | 10 | 16 |
| +— | futility | 0 | 127 | 0 | 59 | 68 |
| +— | max_n | 0 | 0 | 0 | 0 | 0 |
| +— | n | 42 (33, 52) | 14 (7, 32) | 14 (3, 34) | 18 (10, 35) | 20 (9, 39) |
| +— | n_unique | 42 (33, 52) | 14 (7, 32) | 14 (3, 34) | 18 (10, 35) | 20 (9, 39) |
| +— | post_p | NA (NA, NA) | 0.23 (0.04, 0.57) | 0.84 (0.48, 0.98) | 0.31 (0.06, 0.74) | 0.37 (0.09, 0.78) |
| +— | rate | 0.017 (0.013, 0.025) | 0.026 (0.018, 0.045) | 0.01 (0.005, 0.02) | 0.023 (0.015, 0.036) | 0.021 (0.014, 0.035) |
| +–+ | graduation | 0 | 2 | 411 | 13 | 16 |
| +–+ | futility | 0 | 267 | 0 | 153 | 189 |
| +–+ | max_n | 0 | 0 | 0 | 0 | 0 |
| +–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| +–+ | rate | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.013 (0, 0.444) | 0.032 (0.032, 0.032) |
| +-+- | graduation | 0 | 1 | 414 | 11 | 19 |
| +-+- | futility | 0 | 233 | 1 | 155 | 142 |
| +-+- | max_n | 0 | 0 | 0 | 0 | 0 |
| +-+- | n | 30 (22, 39) | 12 (5, 24) | 9 (2, 22) | 14 (7, 26) | 14 (6, 27) |
| +-+- | n_unique | 30 (22, 39) | 12 (5, 24) | 9 (2, 22) | 14 (7, 26) | 14 (6, 27) |
| +-+- | post_p | NA (NA, NA) | 0.26 (0.06, 0.66) | 0.79 (0.41, 0.96) | 0.33 (0.08, 0.7) | 0.4 (0.1, 0.77) |
| +-+- | rate | 0.018 (0.012, 0.025) | 0.027 (0.015, 0.048) | 0.01 (0.002, 0.023) | 0.023 (0.015, 0.04) | 0.021 (0.012, 0.04) |
| +-++ | graduation | 0 | 2 | 442 | 12 | 19 |
| +-++ | futility | 0 | 323 | 1 | 215 | 230 |
| +-++ | max_n | 0 | 0 | 0 | 0 | 0 |
| +-++ | n | 6 (3, 10) | 3 (1, 7) | 2 (0, 5) | 4 (1, 8) | 4 (1, 8) |
| +-++ | n_unique | 6 (3, 10) | 3 (1, 7) | 2 (0, 5) | 4 (1, 8) | 4 (1, 8) |
| +-++ | post_p | NA (NA, NA) | 0.45 (0.26, 0.62) | 0.56 (0.41, 0.73) | 0.47 (0.27, 0.66) | 0.47 (0.29, 0.64) |
| +-++ | rate | 0.016 (0, 0.038) | 0.028 (0, 0.071) | 0.009 (0, 0.038) | 0.022 (0.005, 0.065) | 0.023 (0.005, 0.056) |
| ++– | graduation | 0 | 3 | 434 | 12 | 20 |
| ++– | futility | 0 | 325 | 1 | 185 | 206 |
| ++– | max_n | 0 | 0 | 0 | 0 | 0 |
| ++– | n | 1 (0, 3) | 1 (0, 2) | 0 (0, 1) | 1 (0, 2) | 1 (0, 2) |
| ++– | n_unique | 1 (0, 3) | 1 (0, 2) | 0 (0, 1) | 1 (0, 2) | 1 (0, 2) |
| ++– | post_p | NA (NA, NA) | 0.49 (0.42, 0.56) | 0.53 (0.44, 0.57) | 0.49 (0.43, 0.56) | 0.5 (0.44, 0.55) |
| ++– | rate | 0.008 (0, 0.075) | 0.022 (0, 0.126) | 0 (0, 0.045) | 0.019 (0, 0.126) | 0.018 (0, 0.095) |
| ++-+ | graduation | 0 | 4 | 449 | 13 | 20 |
| ++-+ | futility | 0 | 369 | 1 | 233 | 255 |
| ++-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++-+ | n | 8 (4, 13) | 4 (1, 8) | 2 (0, 6) | 5 (2, 10) | 4 (2, 11) |
| ++-+ | n_unique | 8 (4, 13) | 4 (1, 8) | 2 (0, 6) | 5 (2, 10) | 4 (2, 11) |
| ++-+ | post_p | NA (NA, NA) | 0.43 (0.22, 0.64) | 0.59 (0.4, 0.82) | 0.45 (0.25, 0.72) | 0.46 (0.24, 0.68) |
| ++-+ | rate | 0.017 (0.006, 0.035) | 0.026 (0.009, 0.068) | 0.009 (0, 0.035) | 0.023 (0.009, 0.055) | 0.023 (0.009, 0.061) |
| +++- | graduation | 0 | 3 | 456 | 13 | 21 |
| +++- | futility | 0 | 382 | 1 | 248 | 251 |
| +++- | max_n | 0 | 0 | 0 | 0 | 0 |
| +++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| +++- | rate | 0 (0, 0) | 0.046 (0.046, 0.046) | 0 (0, 0.037) | 0.006 (0, 0.038) | 0 (0, 0.057) |
| ++++ | graduation | 0 | 4 | 466 | 13 | 21 |
| ++++ | futility | 0 | 406 | 1 | 279 | 289 |
| ++++ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | post_p | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.43 (0.43, 0.43) | NA (NA, NA) |
| ++++ | rate | 0 (0, 0.07) | 0.019 (0, 0.054) | 0 (0, 0.143) | 0.044 (0, 0.13) | 0 (0, 0.128) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities